Description

1-Chloro-2-ethoxyethane (CAS No. 628-34-2) is a high-purity organic compound with the molecular formula C₄H₉ClO. This colorless to pale yellow liquid is widely utilized in synthetic organic chemistry and industrial applications due to its reactive chloroethoxy functional group. With a boiling point of approximately 117-118°C and a density of 1.01 g/cm³, it serves as a versatile building block for etherification and alkylation reactions. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied in amber glass bottles or sealed drums to maintain stability. Ideal for researchers requiring precise stoichiometry in nucleophilic substitutions or phase-transfer catalysis.

Key Features:

• IUPAC Name: 1-Chloro-2-ethoxyethane
• Synonyms: 2-Chloroethyl ethyl ether, 2-Ethoxyethyl chloride
• Molecular Weight: 108.57 g/mol
• Refractive Index: n²⁰_D 1.419-1.421
• Flash Point: 25°C (closed cup)

Store in a cool, dry place under inert atmosphere. Compatible with common organic solvents but reacts violently with strong oxidizers.

Properties

• CAS Number: 628-34-2
• Complexity: 23.5
• IUPAC Name: 1-chloro-2-ethoxy-ethane
• InChI: InChI=1S/C4H9ClO/c1-2-6-4-3-5/h2-4H2,1H3
• InChI Key: GPTVQTPMFOLLOA-UHFFFAOYSA-N
• Exact Mass: 108.0341926
• Molecular Formula: C4H9ClO
• Molecular Weight: 108.57
• SMILES: CCOCCCl
• Topological: 9.2
• Monoisotopic Mass: 108.0341926
• Synonyms: 2-Chloroethyl ethyl ether, 1-CHLORO-2-ETHOXYETHANE, 2-Ethoxyethyl chloride, 2-Chloroethoxyethane, Ethane, 1-chloro-2-ethoxy-, Ether, 2-chloroethyl ethyl, beta-Chloroethyl ethyl ether, Ethyl beta-chloroethyl ether, CCRIS 9095, EINECS 211-037-9, BRN 1731361, DTXSID10211882, DTXCID40134373, Ethane, 1-chloro-2-ethoxy-(9CI), 211-037-9, 628-34-2, 2-Chloroethylethylether, 1-chloro-2-ethoxy-ethane, 2-Chlorodiethyl ether, (2-chloroethoxy)ethane, 2-chloro-1-ethoxyethane, beta-Chlorodiethyl ether, MFCD00000974, chloroethylethyl ether, Ethane, 1-chloro-2-ethoxy- (9CI), chloroethyl ethyl ether, 2-chloroethylethyl ether, 2-chloroethyl-ethyl ether, 2NLQ3AZ36L, SCHEMBL39037, SCHEMBL39038, Chloroethyl ethyl ether, 2-, SCHEMBL115596, .beta.-Chloroethyl ethyl ether, Ethyl .beta.-chloroethyl ether, SCHEMBL11413329, 2-Chloroethyl ethyl ether, 99%, BCP15316, SBB061015, AKOS009157288, AS-75545, FC153286, DB-054301, C1172, NS00035189, ST51047095, EN300-51716, F0001-1693

Application

1-Chloro-2-ethoxyethane is primarily employed as an alkylating agent in the synthesis of heterocyclic compounds and pharmaceutical intermediates. Its bifunctional reactivity enables participation in Williamson ether synthesis and nucleophilic displacement reactions. Researchers value this compound for modifying polymer side chains and creating crosslinked hydrogels in material science. In agrochemical production, it serves as a precursor for herbicidal formulations requiring ethoxy-chloro moieties.

Safety and Hazards

GHS Hazard Statements

• H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H301 (89.1%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (13%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (13%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (89.1%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H332 (10.9%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (10.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (100%)
• Acute Tox. 3 (89.1%)
• Skin Irrit. 2 (13%)
• Eye Irrit. 2A (13%)
• Acute Tox. 3 (89.1%)
• Acute Tox. 4 (10.9%)
• STOT SE 3 (10.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.