Description

(E)-tert-Butyl 3-(4-formylphenyl)acrylate (CAS No. 144374-53-8) is a high-purity organic compound with the molecular formula C₁₄H₁₆O₃. This ester derivative features a reactive formyl group and an acrylate moiety, making it a versatile intermediate for organic synthesis and pharmaceutical research. The compound is supplied as a white to off-white crystalline powder with a molecular weight of 232.28 g/mol. It is characterized by its IUPAC name, tert-butyl (E)-3-(4-formylphenyl)prop-2-enoate, and is ideal for use in cross-coupling reactions, polymer chemistry, and as a precursor for bioactive molecules. Store in a cool, dry place under inert conditions to ensure stability.

Properties

• CAS Number: 144374-53-8
• Complexity: 291
• IUPAC Name: tert-butyl (E)-3-(4-formylphenyl)prop-2-enoate
• InChI: InChI=1S/C14H16O3/c1-14(2,3)17-13(16)9-8-11-4-6-12(10-15)7-5-11/h4-10H,1-3H3/b9-8+
• InChI Key: OFMQCKGSKVARCL-CMDGGOBGSA-N
• Exact Mass: 232.109944368
• Molecular Formula: C14H16O3
• Molecular Weight: 232.27
• SMILES: CC(C)(C)OC(=O)/C=C/C1=CC=C(C=C1)C=O
• Topological: 43.4
• Monoisotopic Mass: 232.109944368
• Synonyms: (E)-tert-Butyl 3-(4-formylphenyl)acrylate, 144374-53-8, 208036-26-4, tert-Butyl 3-(4-formylphenyl)acrylate, Tert-butyl (E)-3-(4-formylphenyl)prop-2-enoate, 2-Propenoic acid, 3-(4-formylphenyl)-, 1,1-dimethylethyl ester, (2E)-, TERT-BUTYL (2E)-3-(4-FORMYLPHENYL)PROP-2-ENOATE, MFCD17214284, SCHEMBL1322439, (E)-3-(4-formyl-phenyl)-acrylic acid tert-butyl ester, OFMQCKGSKVARCL-CMDGGOBGSA-N, tert-Butyl3-(4-formylphenyl)acrylate, AKOS015837474, BS-27386, (E)-tert-butyl-3-(4-formylphenyl)acrylate, DB-310217, EN300-844856, Z2312551825

Application

(E)-tert-Butyl 3-(4-formylphenyl)acrylate is widely used as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. Its formyl group enables further functionalization via condensation or nucleophilic addition reactions, while the acrylate moiety participates in polymerization or Michael additions. Researchers utilize this compound in the development of novel polymers, liquid crystals, and small-molecule inhibitors. It is particularly valuable in medicinal chemistry for constructing conjugated systems or as a scaffold for drug discovery.

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