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Atomfair Droperidol C22H22FN3O2 CAS 548-73-2

Droperidol (CAS: 548-73-2) is a potent butyrophenone-class antipsychotic and antiemetic agent with the molecular formula C22H22FN3O2. Its IUPAC name is 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one . This high-purity compound is supplied as a fine white to off-white crystalline powder, suitable for research and pharmaceutical development. Droperidol exhibits strong dopamine D2receptor antagonism, with additional activity at α1-adrenergic and serotonin receptors. It is highly soluble in organic solvents like ethanol and DMSO, but has limited aqueous solubility. Store at 2-8°C in a tightly sealed container protected from light and moisture. Offered in various quantities with ≥98% HPLC purity, accompanied by comprehensive analytical data (MS, NMR, HPLC).

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Description

Droperidol (CAS: 548-73-2) is a potent butyrophenone-class antipsychotic and antiemetic agent with the molecular formula C22H22FN3O2. Its IUPAC name is 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one. This high-purity compound is supplied as a fine white to off-white crystalline powder, suitable for research and pharmaceutical development. Droperidol exhibits strong dopamine D2 receptor antagonism, with additional activity at α1-adrenergic and serotonin receptors. It is highly soluble in organic solvents like ethanol and DMSO, but has limited aqueous solubility. Store at 2-8°C in a tightly sealed container protected from light and moisture. Offered in various quantities with ≥98% HPLC purity, accompanied by comprehensive analytical data (MS, NMR, HPLC).

Properties

  • CAS Number: 548-73-2
  • Complexity: 615
  • IUPAC Name: 3-[1-[4-(4-fluorophenyl)-4-oxo-butyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
  • InChI: InChI=1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28)
  • InChI Key: RMEDXOLNCUSCGS-UHFFFAOYSA-N
  • Exact Mass: 379.16960512
  • Molecular Formula: C22H22FN3O2
  • Molecular Weight: 379.4
  • SMILES: C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
  • Topological: 52.7
  • Monoisotopic Mass: 379.16960512
  • Physical Description: Solid
  • Color/Form: White to light tan, amorphous or microcrystalline powder
  • Odor: Odorless
  • Taste: Tasteless
  • Melting Point: 145-146.5
  • Solubility: 33.4 [ug/mL]
  • Stability/Shelf Life: Sensitive to light, air & heat
  • Dissociation Constants: 7.6
  • Synonyms: droperidol, 548-73-2, Dehydrobenzperidol, Dridol, Properidol, Sintodril, Sintosian, Halkan, Inapsin, Vetkalm, Deidrobenzperidolo, Inopsin, McN-JR-4749, Inappin, Innovan, Inoval, Droperidolo, Droperidolum, Dihidrobenzperidol, Dehydrobenzoperidol, R-4749, McN-JR 4749, R 4749, NSC 169874, Droperidolum [INN-Latin], 1-(1-(3-(p-Fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone, CCRIS 9070, HSDB 3320, 1-(1-(4-(p-Fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone, R4749, EINECS 208-957-8, UNII-O9U0F09D5X, NSC-169874, BRN 0579168, CHEBI:4717, O9U0F09D5X, DTXSID6022973, NSC169874, 2H-Benzimidazol-2-one, 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridinyl)-1,3-dihydro-, DTXCID302973, 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one, 2H-Benzimidazol-2-one, 1-[1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl]-1,3-dihydro-, INNOVAR COMPONENT DROPERIDOL, 5-24-02-00388 (Beilstein Handbook Reference), 1-[1-[3-(p-Fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone, 1-{1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one, Droperidol [USAN:USP:INN:BAN:JAN], Droperidolum (INN-Latin), DROPERIDOL (MART.), DROPERIDOL [MART.], 2-Benzimidazolinone, 1-(1-(3-(p-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-, DROPERIDOL (USP-RS), DROPERIDOL [USP-RS], 1-(1-(4-(4-Fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridinyl)-1,3-dihydro-2H-benzimidazol-2-one, 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl}-2,3-dihydro-1H-benzo[d]imidazol-2-one, DROPERIDOL (EP MONOGRAPH), DROPERIDOL [EP MONOGRAPH], DROPERIDOL (USP MONOGRAPH), DROPERIDOL [USP MONOGRAPH], Droperidol (USAN:USP:INN:BAN:JAN), 1-[1-[4-(p-Fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone, 2-Benzimidazolinone, 1-[1-[3-(p-fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl]-, 1-(1-[3-(p-fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone, 1-(1-(4-(4-Fluoro-phenyl)-4-oxo-butyl)-1,2,3,6-tetrahydro-pyridin-4-yl)-1,3-dihydro-benzoimidazol-2-one, 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridinyl)-2,3-dihydro-1H-benzo(d)imidazol-2-one, 1-(1-(4-(4-Fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydropyridin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one, N01AX01, N05AD08, DROPERIDOL COMPONENT OF INNOVAR, 208-957-8, 1-(1-(4-(p-fluorophenyl-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone, dhbp, Droleptan, Inapsine, Innovar, Dehidrobenzperidol, Leptofen, Thalamanol, Thalamonal, Innovar-vet, component of Innovar, 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one, CHEMBL1108, MLS000028671, 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-benzo[d]imidazol-2(3H)-one, MFCD00083290, NCGC00016504-01, CAS-548-73-2, Droperidolo [DCIT], SMR000058855, C22H22FN3O2, Neurolidol, Ina.psi.ne, Ina.psi.n, Ino.psi.n, Droleptan (TN), 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one, 3-[1-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-2,3,4,5-tetrahydropyridin-4-yl]-1~{H}-benzimidazol-2-one, SR-05000001546, INAPSINE (TN), Droperidol; 1-[1-[4-(4-Fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one, Prestwick_705, Innovar (Salt/Mix), HS-0065, Leptanal (Salt/Mix), Leptofen (Salt/Mix), Droperidol (Standard), Spectrum_001220, Thalamonal (Salt/Mix), DROPERIDOL [MI], DROPERIDOL [INN], DROPERIDOL [JAN], Innovar-vet (Salt/Mix), Opera_ID_1751, Prestwick0_000360, Prestwick1_000360, Prestwick2_000360, Prestwick3_000360, Spectrum2_001386, Spectrum3_001426, Spectrum4_000407, Spectrum5_001305, DROPERIDOL [HSDB], DROPERIDOL [USAN], DROPERIDOL [VANDF], DROPERIDOL [WHO-DD], SCHEMBL41426, BSPBio_000459, BSPBio_003132, KBioGR_000674, KBioSS_001700, MLS000758203, MLS001148120, MLS001424134, MLS002153445, DivK1c_000103, SPECTRUM1501002, SPBio_001372, SPBio_002380, BPBio1_000505, Droperidol (JP18/USP/INN), GTPL7172, DROPERIDOL [GREEN BOOK], DROPERIDOL [ORANGE BOOK], HMS500F05, HY-B1240R, KBio1_000103, KBio2_001700, KBio2_004268, KBio2_006836, KBio3_002352, NINDS_000103, HMS1569G21, HMS1921B03, HMS2051L06, HMS2092O16, HMS2096G21, HMS2232M09, HMS3374B05, HMS3393L06, HMS3652M12, HMS3713G21, HMS3885N03, HMS5082K12, Pharmakon1600-01501002, HY-B1240, MSK11416, Tox21_110461, BDBM50017705, CCG-39004, NSC757819, s4096, STL453109, AKOS015960779, Tox21_110461_1, AC-3537, CCG-101004, CS-4886, DB00450, FF22616, NC00254, NSC-757819, 1-1-[3-(p-Fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl-2-benzimidazolinone, 3-[1-[4-(4-fluorophenyl)-4-oxo-butyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one, IDI1_000103, NCGC00016504-02, NCGC00016504-03, NCGC00016504-04, NCGC00016504-05, NCGC00016504-06, NCGC00016504-09, NCGC00016504-17, NCGC00094884-01, NCGC00094884-02, DA-52701, SBI-0051628.P002, Droperidol 1.0 mg/ml in Dimethyl Sulfoxide, NS00000026, SW220019-1, D00308, EN300-127036, F17346, AB00052191_04, AB00052191_05, WLN: T56 BMVNJ D3- DT6N CUTJ A3VR DF, A830387, L001006, Q174259, SR-05000001546-1, SR-05000001546-2, SR-05000001546-3, BRD-K97158071-001-05-8, BRD-K97158071-001-08-2, BRD-K97158071-001-17-3, BRD-K97158071-001-18-1, Z1592690523, Droperidol, British Pharmacopoeia (BP) Reference Standard, Droperidol, European Pharmacopoeia (EP) Reference Standard, Droperidol, United States Pharmacopeia (USP) Reference Standard, 2H-Benzimidazol-2-one,2,3,6-tetrahydro-4-pyridinyl]-1,3-dihydro-, 1-[1-[3-(p-Fluorobenzoyl)propyl]-1,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone, 1-[1-[4-(p-Fluorophenyl)-4-oxobutyl]-1,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone, 1-1-[3-(p-Fluorobenzoyl)propyl]-1,3,6-tetrahydro-4-pyridyl-2-benzimidazolinone, gamma-[4-(2-oxo-1-benzimidazolinyl)-1,2,3,6-tetrahydro-1-pyridyl]-p-fluorobutyrophenone, 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydropyridin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one, 1-(1-(4-(P-FLUOROPHENYL-4-OXOBUTYL)-1,2,3,6-TETRAHYDRO- 4-PYRIDYL)-2-BENZIMIDAZOLINONE, 1-(4-fluorophenyl)-4-[4-(2-hydroxy-1H-1,3-benzodiazol-1-yl)-1,2,3,6-tetrahydropyridin-1-yl]butan-1-one, 1-[1-[4-(4-fluorophenyl)-4-oxo-butyl]-3,6-dihydro-2H-pyridin-4-yl]-3H-benzoimidazol-2-one, 1-[1-[4-(4-Fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl]-1,3-dihydro-2H-benzimidazol-2-one;Dehydrobenzperidol;Dridol, 1-{1-[4-(4-Chloro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one(Droperidol), 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,5,6-tetrahydropyridin-4-yl] -1,3-dihydro-2H-benzimidazol}-2-one, 3-[1-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one, USS

Application

Droperidol is primarily used in research settings to study its neuroleptic and antiemetic properties. It serves as a reference standard in pharmacological studies of dopamine receptor antagonists. The compound is also investigated for its potential in managing postoperative nausea and vomiting (PONV) in clinical research. Additionally, Droperidol is utilized in neuroscience research exploring the mechanisms of antipsychotic drugs.

Safety and Hazards

GHS Hazard Statements

  • H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

Precautionary Statements

  • P264, P270, P301+P317, P330, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (100%)

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