Description

(Difluoromethyl)trimethylsilane (CAS No. 65864-64-4) is a highly versatile organosilicon compound with the molecular formula C₄H₁₀F₂Si. This reagent is widely used in organic synthesis, particularly as a nucleophilic difluoromethylating agent due to its ability to introduce the difluoromethyl group (-CF₂H) into various substrates. Its IUPAC name, difluoromethyl(trimethyl)silane, reflects its structural composition, featuring a reactive difluoromethyl moiety bound to a trimethylsilyl group.

With a purity grade suitable for research and industrial applications, this compound is stored under inert conditions to ensure stability. It is commonly employed in pharmaceutical, agrochemical, and materials science research for the synthesis of fluorinated compounds, which are critical in drug discovery and advanced material development. The reagent is compatible with a range of reaction conditions, including Grignard reactions, cross-coupling, and nucleophilic additions.

Available in various quantities, (Difluoromethyl)trimethylsilane is supplied in rigorously tested packaging to guarantee safety and longevity. Its applications span from small-scale laboratory experiments to large-scale industrial processes, making it a valuable tool for synthetic chemists and researchers.

Properties

• CAS Number: 65864-64-4
• Complexity: 55.2
• IUPAC Name: difluoromethyl(trimethyl)silane
• InChI: InChI=1S/C4H10F2Si/c1-7(2,3)4(5)6/h4H,1-3H3
• InChI Key: OOKFLLNDYNWCHK-UHFFFAOYSA-N
• Exact Mass: 124.05198318
• Molecular Formula: C4H10F2Si
• Molecular Weight: 124.20
• SMILES: C[Si](C)(C)C(F)F
• Monoisotopic Mass: 124.05198318
• Synonyms: (difluoromethyl)trimethylsilane, 804-145-8, 65864-64-4, Difluoromethyltrimethylsilane, Silane, (difluoromethyl)trimethyl-, (Difluoromethyl)(trimethyl)silane, difluoromethyl(trimethyl)silane, Difluoromethyl-trimethyl-silane, Difluoromethyl)trimethylsilane, Me3Sicf2H, MFCD19381658, C4H10F2Si, trimethyl(difluoromethyl)silane, SCHEMBL4854565, SCHEMBL14777329, DTXSID20457496, BCP32220, BBL103460, STL557270, AKOS015913928, FD60404, SB38170, AS-53422, DB-351193, D4364, EN300-106165, P16466, (Difluoromethyl)trimethylsilane, >=98.0% (GC), (Difluoromethyl)trimethylsilane;Difluoromethyltrimethylsilane

Application

(Difluoromethyl)trimethylsilane is primarily used as a difluoromethylating agent in organic synthesis, enabling the introduction of the -CF₂H group into target molecules. It is particularly valuable in pharmaceutical research for the preparation of fluorinated analogs of bioactive compounds, enhancing their metabolic stability and lipophilicity. Additionally, this reagent finds utility in materials science for modifying surfaces or polymers with fluorinated groups to impart unique properties such as hydrophobicity or chemical resistance. Its compatibility with a variety of reaction conditions makes it a preferred choice for synthetic chemists working on complex fluorinated architectures.

Safety and Hazards

GHS Hazard Statements

• H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (100%)

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