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Atomfair Difluoromethyl 4-methylbenzenesulfonate C8H8F2O3S

Description Difluoromethyl 4-methylbenzenesulfonate (CAS No. 14277-20-4) is a high-purity sulfonate ester with the molecular formula C8H8F2O3S . This specialized chemical compound is widely utilized in organic synthesis, pharmaceutical research, and material science due to its unique reactivity as a difluoromethylating agent. The compound features a 4-methylbenzenesulfonate (tosylate) group, which enhances its stability and handling properties while maintaining excellent leaving-group characteristics for nucleophilic substitution reactions. Our product is rigorously tested to ensure ??95% purity (by GC or HPLC) and is supplied in sealed, light-resistant containers under inert atmosphere to prevent degradation. Ideal for researchers developing fluorinated compounds, this reagent offers precise…

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Description

Description

Difluoromethyl 4-methylbenzenesulfonate (CAS No. 14277-20-4) is a high-purity sulfonate ester with the molecular formula C8H8F2O3S. This specialized chemical compound is widely utilized in organic synthesis, pharmaceutical research, and material science due to its unique reactivity as a difluoromethylating agent. The compound features a 4-methylbenzenesulfonate (tosylate) group, which enhances its stability and handling properties while maintaining excellent leaving-group characteristics for nucleophilic substitution reactions. Our product is rigorously tested to ensure ??95% purity (by GC or HPLC) and is supplied in sealed, light-resistant containers under inert atmosphere to prevent degradation. Ideal for researchers developing fluorinated compounds, this reagent offers precise control in introducing the difluoromethyl moiety into target molecules.

Key applications include: synthesis of fluorinated pharmaceuticals, agrochemicals, and advanced materials; cross-coupling reactions; and as a building block for complex organic frameworks. Store in a cool, dry place at 2-8??C under inert conditions. For research use only; not for drug or household use.

  • CAS No: 14277-20-4
  • Molecular Formula: C8H8F2O3S
  • Molecular Weight: 222.21
  • Exact Mass: 222.01622161
  • Monoisotopic Mass: 222.01622161
  • IUPAC Name: difluoromethyl 4-methylbenzenesulfonate
  • SMILES: CC1=CC=C(C=C1)S(=O)(=O)OC(F)F
  • Synonyms: difluoromethyl 4-methylbenzenesulfonate, 14277-20-4, Methanol, 1,1-difluoro-, 1-(4-methylbenzenesulfonate), SCHEMBL872063, ZNMVZAWTNZJSGF-UHFFFAOYSA-N

Application

Difluoromethyl 4-methylbenzenesulfonate serves as a versatile reagent in medicinal chemistry for the incorporation of difluoromethyl groups into bioactive molecules, enhancing metabolic stability and lipophilicity. It is particularly valuable in the synthesis of fluorinated analogs of pharmaceuticals and agrochemicals where the difluoromethyl group modulates electronic and steric properties. The compound also finds use in materials science for the preparation of fluorinated polymers with tailored surface characteristics.

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