Description

(Diethylamino)trimethylsilane (CAS: 996-50-9) is a highly versatile organosilicon compound with the molecular formula C₇H₁₉NSi and IUPAC name N-ethyl-N-trimethylsilylethanamine. This clear, colorless liquid is widely used as a silylating agent in organic synthesis, offering excellent reactivity for the protection of amines, alcohols, and other functional groups. Its low boiling point and moisture sensitivity make it ideal for inert atmosphere applications. Packaged under nitrogen to ensure stability, this reagent is a critical tool for researchers in pharmaceuticals, materials science, and fine chemical synthesis. Available in high-purity grades (≥98%), it is suitable for demanding laboratory and industrial processes.

Properties

• CAS Number: 996-50-9
• Complexity: 71.5
• IUPAC Name: N-ethyl-N-trimethylsilyl-ethanamine
• InChI: InChI=1S/C7H19NSi/c1-6-8(7-2)9(3,4)5/h6-7H2,1-5H3
• InChI Key: JOOMLFKONHCLCJ-UHFFFAOYSA-N
• Exact Mass: 145.128676145
• Molecular Formula: C7H19NSi
• Molecular Weight: 145.32
• SMILES: CCN(CC)[Si](C)(C)C
• Topological: 3.2
• Monoisotopic Mass: 145.128676145
• Physical Description: Colorless liquid;
• Synonyms: 996-50-9, N,N-Diethyl-1,1,1-trimethylsilylamine, Diethylaminotrimethylsilane, (Diethylamino)trimethylsilane, Silanamine, N,N-diethyl-1,1,1-trimethyl-, (trimethylsilyl)diethylamine, NSC 377650, 5LP9WK7P33, EINECS 213-637-6, NSC-377650, Silylamine, N,N-diethyl-1,1,1-trimethyl-, DTXSID5061370, TRIMETHYL(DIETHYLAMINO)SILANE, N(Trimethylsilyl)diethylamine, DTXCID2049133, Silanamine, N,Ndiethyl1,1,1trimethyl, 213-637-6, n,n-diethyl-1,1,1-trimethylsilanamine, N,N-Diethyltrimethylsilylamine, Trimethylsilyldiethylamine, N,N-Diethylaminotrimethylsilane, N-(Trimethylsilyl)diethylamine, N-ethyl-N-trimethylsilylethanamine, N-Trimethylsilyldiethylamine, diethyl(trimethylsilyl)amine, TMSDEA, TMS-DEA, Diethylamine, TMS derivative, n,n-diethyl(trimethylsilyl)amine, Trimethyl-N,N-diethylaminosilane, (CH3)3SiN(C2H5)2, MFCD00009040, NSC377650, Me3SiNEt2, Trimethylsilyl-diethylamin, trimethylsilyl-diethylamine, UNII-5LP9WK7P33, Diethyl-trimethylsilanyl-amine, SCHEMBL230819, isobutyl 3-cyclohexylpropanoate, N,N-Diethyl-trimethylsilylamine, SCHEMBL9845415, (n,n-diethylamino)trimethylsilane, CHEBI:85070, N,N-Diethyl(trimethyl)silanamine #, CD4450, N,N-Diethyltrimethylsilylamine, 97%, AKOS005216073, FS-3954, NS00043073, T0492, EN300-214831, S06325, Q3869305, InChI=1/C7H19NSi/c1-6-8(7-2)9(3,4)5/h6-7H2,1-5H

Application

(Diethylamino)trimethylsilane is primarily employed as a silylation reagent for introducing the trimethylsilyl (TMS) group into organic molecules, enabling protection of sensitive functional groups during synthesis. It is particularly useful in peptide chemistry and the modification of nucleosides or steroids. The compound also serves as a precursor in the production of silicon-based polymers and coatings, enhancing thermal and chemical resistance. Its reactivity with protic compounds makes it valuable for moisture scavenging in anhydrous reactions.

Safety and Hazards

GHS Hazard Statements

• H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H314 (98.6%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (100%)
• Skin Corr. 1B (98.6%)

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