Description

Diethylaminosulfur Trifluoride (DAST) is a highly reactive fluorinating agent with the molecular formula C₄H₁₀F₃NS. This organosulfur compound is widely utilized in organic synthesis for the selective conversion of alcohols to alkyl fluorides, aldehydes/ketones to gem-difluorides, and carboxylic acids to acyl fluorides. Its IUPAC name, N-ethyl-N-(trifluoro-λ⁴-sulfanyl)ethanamine, reflects its structural composition. DAST is a colorless to pale yellow liquid with a pungent odor, requiring careful handling under inert conditions due to its moisture sensitivity and potential for exothermic decomposition. Packaged in amber glass bottles under nitrogen to ensure stability, this reagent is ideal for researchers in pharmaceuticals, agrochemicals, and materials science seeking precise fluorination.

Key Features:

• CAS Number: 38078-09-0
• High purity (>98%) for reliable results
• Compatible with anhydrous solvents like THF and DCM
• Stored under nitrogen to prevent degradation

Properties

• CAS Number: 38078-09-0
• Complexity: 78.4
• IUPAC Name: N-ethyl-N-(trifluoro-lambda4-sulfanyl)ethanamine
• InChI: InChI=1S/C4H10F3NS/c1-3-8(4-2)9(5,6)7/h3-4H2,1-2H3
• InChI Key: CSJLBAMHHLJAAS-UHFFFAOYSA-N
• Exact Mass: 161.04860498
• Molecular Formula: C4H10F3NS
• Molecular Weight: 161.19
• SMILES: CCN(CC)S(F)(F)F
• Topological: 4.2
• Monoisotopic Mass: 161.04860498
• Synonyms: Diethylaminosulfur trifluoride, 38078-09-0, (Diethylamino)sulfur trifluoride, (Diethylamino)sulphur trifluoride, diethylaminosulfate trifluoride, UNII-78622BV6IJ, 78622BV6IJ, (DIETHYLAMINO)TRIFLUOROSULFUR, EINECS 253-771-2, trifluoro(diethylamino)sulfur, (T-4)-(N-Ethylethanaminato)trifluorosulfur, DAST (FLUORINATING AGENT), DTXSID20191484, (n,n-diethylamino)sulfur trifluoride, DIETHYLAMINOSULFUR TRIFLUORIDE [MI], Sulfur, (N-ethylethanaminato)trifluoro-, (beta-4)-, DTXCID30113975, DAST, diethylaminosulfurtrifluoride, diethylaminosulphur trifluoride, diethylaminosulphurtrifluoride, N-ETHYL-N-(TRIFLUORO-LAMBDA4-SULFANYL)ETHANAMINE, diethyl aminosulfurtrifluoride, diethyl(trifluoro-lambda4-sulfanyl)amine, MFCD00000363, C4H10F3NS, Sulfur, (N-ethylethanaminato)trifluoro-, (T-4)-, diethylaminosulfurtrifloride, N,N-diethyl-1,1,1-trifluoro-l4-sulfanamine, diethylaminosulfur trifloride, SCHEMBL1693, Diethylaminosulfur trifluorid, diethylamino sulfurtrifluoride, diethylaminosulfer trifluoride, diethylaminosulfur triflouride, (Diethylamino) trifluorosulfur, diethylamino sulfur trifluoride, diethylamino-sulfur trifluoride, diethylamino-sulfur-trifluoride, diethylamino sulphur trifluoride, diethylamino-sulphur trifluoride, (Diethylamino)sulfer trifluoride, (diethylamino)-sulfur trifluoride, N,N-diethlaminosulfur trifluoride, (Diethylamino) sulfur trifluoride, N,N-diethylaminosulfur trifluoride, BCP12989, (N-ethylethanaminato)-trifluorosulfur, BBL101603, FD2004, SBB087527, STL555399, diethylaminosulfur trifluoride (DAST), AKOS005063399, CS-W004256, FD02546, GS-3627, DB-001351, D1868, ST51038085, EN300-97056, N-ethyl-N-(trifluor-lambda4-sulfanyl)ethanamin, A824005, N-ethyl-N-(trifluoro-^{4}-sulfanyl)ethanamine, Q412982, N-ethyl-N-(trifluoro-lambda~4~-sulfanyl)ethanamine, n-ethyl-n-(trifluoro-lambda4-sulfanyl)-1-ethanamine, n-ethyl-n-(trifluoro-lambda4-sulphanyl)-1-ethanamine, F0001-1088, N-ethyl-N-[tris(fluoranyl)-^{4}-sulfanyl]ethanamine, (Diethylamino)sulfur trifluoride, technical, packed in PTFE bottles, >=90% (NMR)

Application

Diethylaminosulfur Trifluoride (DAST) is primarily used as a fluorinating agent in organic synthesis to convert alcohols to alkyl fluorides and carbonyl compounds to gem-difluorides. It is particularly valuable in pharmaceutical research for introducing fluorine atoms into bioactive molecules to enhance metabolic stability and bioavailability. DAST also finds applications in materials science for modifying surface properties and synthesizing fluorinated polymers.

Safety and Hazards

GHS Hazard Statements

• H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
• H302 (86.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (86.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H332 (86.9%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P370+P378, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Acute Tox. 4 (86.9%)
• Acute Tox. 4 (86.9%)
• Skin Corr. 1B (100%)
• Acute Tox. 4 (86.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.