Description

Cyperquat Iodide (1-Methyl-4-phenylpyridinium iodide) is a high-purity organic salt widely used in neuroscience and biochemistry research as a potent neurotoxin and mitochondrial complex I inhibitor. This compound, with the molecular formula C₁₂H₁₂IN and CAS number 36913-39-0, is supplied as a fine crystalline powder with ≥98% purity (HPLC). It is soluble in water, DMSO, and methanol, making it suitable for in vitro and in vivo studies related to Parkinson’s disease models, oxidative stress research, and dopaminergic neuron degeneration. Store desiccated at -20°C protected from light.

Key Applications: Neurodegeneration studies | Mitochondrial dysfunction research | Cell culture models of Parkinson’s disease

Handling: Use appropriate personal protective equipment. Avoid inhalation and direct contact.

Properties

• CAS Number: 36913-39-0
• Complexity: 141
• IUPAC Name: 1-methyl-4-phenyl-pyridin-1-ium;iodide
• InChI: InChI=1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
• InChI Key: RFDFRDXIIKROAI-UHFFFAOYSA-M
• Exact Mass: 297.00145
• Molecular Formula: C12H12IN
• Molecular Weight: 297.13
• SMILES: C[N+]1=CC=C(C=C1)C2=CC=CC=C2.[I-]
• Topological: 3.9
• Monoisotopic Mass: 297.00145
• Synonyms: 36913-39-0, 1-Methyl-4-phenylpyridinium iodide, N-Methyl-4-phenylpyridinium iodide, Cyperquat iodide, MPP iodide, Pyridinium, 1-methyl-4-phenyl-, iodide, N708D004VE, DTXSID40880040, Pyridinium, 1-methyl-4-phenyl-, iodide (1:1), DTXCID101021648, 627-416-0, MPP+ iodide, 1-Methyl-4-phenylpyridin-1-ium iodide, MPP+ (iodide), 1-methyl-4-phenylpyridin-1-ium;iodide, CHEMBL271379, N-Methyl-4-phenylpyridiniumIodide, UNII-N708D004VE, MFCD00055096, SCHEMBL2203363, CHEBI:232401, RFDFRDXIIKROAI-UHFFFAOYSA-M, HMS6018G11, s6301, 1-Methyl-4-phenylpyridin-1-iumiodide, AKOS030254849, CS-W009435, FM25717, HY-W008719, AC-37889, MPP+ iodide, >=98% (HPLC), powder, DB-255801, 1-Methyl-4-phenylpyridinium iodide;MPP+ iodide, D95477, Q27284640

Cyperquat iodide is primarily used to induce Parkinsonian symptoms in laboratory models by selectively inhibiting mitochondrial complex I. Researchers employ it to study dopaminergic neuron degeneration mechanisms (typically at 10-100 μM concentrations in cell culture). It serves as a positive control in neuroprotection assays and helps investigate oxidative stress pathways in neurodegenerative diseases. The compound is also valuable for screening potential neuroprotective compounds.

Safety and Hazards

GHS Hazard Statements

• H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
• H311 (100%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (100%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (100%)
• Acute Tox. 3 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 3 (100%)
• STOT SE 3 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.