Description

Cyclopropylboronic Acid (CAS: 411235-57-9) is a highly versatile boronic acid derivative with the molecular formula C₃H₇BO₂. This organoboron compound is widely utilized in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds with exceptional efficiency. The cyclopropyl moiety imparts unique steric and electronic properties, making it valuable in pharmaceutical, agrochemical, and materials science research. Available in high purity (typically ≥95%), this white to off-white crystalline powder is stable under standard conditions but should be stored in a cool, dry environment to prevent degradation. Suitable for use in both academic and industrial R&D settings, it is packaged under inert gas to ensure optimal shelf life and reactivity.

Properties

• CAS Number: 411235-57-9
• Complexity: 50.8
• IUPAC Name: cyclopropylboronic acid
• InChI: InChI=1S/C3H7BO2/c5-4(6)3-1-2-3/h3,5-6H,1-2H2
• InChI Key: WLVKDFJTYKELLQ-UHFFFAOYSA-N
• Exact Mass: 86.0539096
• Molecular Formula: C3H7BO2
• Molecular Weight: 85.90
• SMILES: B(C1CC1)(O)O
• Topological: 40.5
• Monoisotopic Mass: 86.0539096
• Synonyms: Cyclopropylboronic acid, 411235-57-9, DTXSID00375402, DTXCID20326431, 609-890-0, Cyclopropyl Boronic Acid, MFCD04038750, CYCLOPROPANEBORONIC ACID, Cyclopropylboronicacid, cyclopropyl-boronic acid, BORONIC ACID, CYCLOPROPYL-, cyclopropylboranediol, cyclopropyboronic acid, cyclopropylboromc acid, cycloproylboronic acid, cyclopropanboronic acid, cylcopropylboronic acid, cyclopropyl boronic cid, cycloproyl boronic acid, cyclo-propylboronic acid, cyclopropanylboronic acid, cyclopropane boronic acid, cyclo-propyl boronic acid, SCHEMBL9068, BCP27024, CS-D1018, BBL104367, STL558619, ZB0043, AKOS004119250, AB17174, AC-6414, FC63289, GS-6568, NCGC00249445-01, BP-10013, HY-59219, SY004028, DB-014145, EN300-30595, Cyclopropylboronic acid pound contains varying amounts of Anhydride pound(c)

Cyclopropylboronic acid is a key reagent in Suzuki-Miyaura cross-coupling reactions, facilitating the synthesis of cyclopropyl-containing compounds for drug discovery. It is employed in the preparation of bioactive molecules, including antiviral and anticancer agents, due to its ability to introduce the cyclopropyl group into complex structures. Researchers also use it in material science to modify polymers and create advanced functional materials. Its stability and reactivity make it ideal for catalytic transformations in both homogeneous and heterogeneous systems.

Safety and Hazards

GHS Hazard Statements

• H242 (20%): Heating may cause a fire [Danger Self-reactive substances and mixtures; Organic peroxides]
• H302 (40%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (13.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (66.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (66.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H360 (13.3%): May damage fertility or the unborn child [Danger Reproductive toxicity]

Precautionary Statements

• P203, P210, P234, P235, P240, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403, P403+P233, P405, P410, P411, P420, and P501

Hazard Classes and Categories

• Self-react. C (20%)
• Acute Tox. 4 (40%)
• Skin Irrit. 2 (66.7%)
• Eye Dam. 1 (13.3%)
• Eye Irrit. 2 (66.7%)
• STOT SE 3 (66.7%)
• Repr. 1B (13.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.