Description

Description

Cyclopropanesulfonyl chloride (CAS No. 139631-62-2) is a highly reactive organosulfur compound with the molecular formula C₃H₅ClO₂S. This versatile sulfonyl chloride derivative features a cyclopropane ring, offering unique steric and electronic properties for synthetic applications. The compound is a clear to pale yellow liquid with a pungent odor, typically stored under inert conditions due to its moisture sensitivity. With a molecular weight of 140.59 g/mol, it serves as a valuable building block in organic synthesis, particularly for introducing the cyclopropanesulfonyl moiety. The product is available in high purity grades (>95%) suitable for research and industrial applications, packaged under nitrogen in amber glass vials to ensure stability.

Key applications include its use as:

• A sulfonylation reagent for amines and alcohols
• A precursor for cyclopropanesulfonamide derivatives
• An intermediate in pharmaceutical and agrochemical synthesis

Technical specifications include:

• Boiling point: ~85-90??C at reduced pressure
• Density: ~1.3 g/mL at 25??C
• Refractive index: n_D²⁰ ~1.48

Handle with appropriate precautions using proper PPE and under fume hood conditions.

Application

Cyclopropanesulfonyl chloride is primarily employed as a key intermediate in medicinal chemistry for the synthesis of sulfonamide-based drug candidates. The strained cyclopropane ring confers unique conformational properties to resulting compounds, making it valuable for structure-activity relationship studies. In materials science, it serves as a precursor for sulfonated polymers with enhanced thermal stability. The compound’s reactivity with nucleophiles enables efficient preparation of various sulfonate esters and sulfonamides for catalytic and biological applications.

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