Description

Clothianidin (CAS No. 210880-92-5) is a highly effective neonicotinoid insecticide with the molecular formula C₆H₈ClN₅O₂S. This systemic pesticide is widely recognized for its broad-spectrum activity against sucking and chewing pests, including aphids, whiteflies, thrips, and beetles. Its unique mode of action involves binding to nicotinic acetylcholine receptors (nAChRs) in the insect nervous system, leading to overstimulation, paralysis, and death. Clothianidin exhibits excellent translaminar and xylem-mobile properties, ensuring thorough plant protection when applied as a soil treatment, seed coating, or foliar spray.

This technical-grade compound is formulated for agricultural and research applications, available as a high-purity analytical standard or commercial-grade product. Its low mammalian toxicity and selective insecticidal activity make it a preferred choice for integrated pest management (IPM) systems. Clothianidin is compatible with various formulation types including wettable powders, suspension concentrates, and seed treatment formulations.

For research use, this product is supplied with comprehensive analytical documentation including HPLC chromatograms, NMR spectra, and certificate of analysis. Proper handling procedures should be followed as with all agricultural chemicals – use personal protective equipment and follow local regulatory guidelines for application rates and safety precautions.

Properties

• CAS Number: 210880-92-5
• Complexity: 258
• IUPAC Name: 1-[(2-chlorothiazol-5-yl)methyl]-3-methyl-2-nitro-guanidine
• InChI: InChI=1S/C6H8ClN5O2S/c1-8-6(11-12(13)14)10-3-4-2-9-5(7)15-4/h2H,3H2,1H3,(H2,8,10,11)
• InChI Key: PGOOBECODWQEAB-UHFFFAOYSA-N
• LogP: log Kow = 0.7 at 25 deg
• Exact Mass: 249.0087234
• Molecular Formula: C6H8ClN5O2S
• Molecular Weight: 249.68
• SMILES: CN/C(=N[N+](=O)[O-])/NCC1=CN=C(S1)Cl
• Topological: 123
• Monoisotopic Mass: 249.0087234
• Physical Description: White solid; Colorless odorless solid; Pale yellow crystalline powder;
• Color/Form: Colorless powder
• Odor: Odorless
• Melting Point: 176.8 °C
• Solubility: In water, 0.304 , 0.340
• Density: 1.61 g/cu cm at 20 °C
• Vapor Pressure: 1.3X10-7 mPa at 25 °C
• Henry’s Law Constant: Henry’s Law constant = 2.9X10-16 atm-cu m/mol at 20 °C
• Stability/Shelf Life: Stable under recommended storage conditions.
• Dissociation Constants: pKa = 11.09 at 20 °C
• Synonyms: Clothianidin, 210880-92-5, Celero, Clothianidin [ISO], Poncho, TI 435, Poncho 600, Pancho, TI-435, 2V9906ABKQ, DTXSID2034465, HSDB 7281, CLOTHIANIDIN [MI], 1-[(2-chloro-1,3-thiazol-5-yl)methyl]-3-methyl-2-nitroguanidine, CCRIS 9264, DTXCID0014465, CGA-322704, ((e)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine), (E)-1-(2-Chloro-1,3-thiazole-5-ylmethyl)-3-methyl-2-nitroguanidine, Guanidine, N-(2-chloro-5-thiazolyl)methyl-N’-methyl-N”-nitro-, (E)-, EC 433-460-1, N-((2-CHLORO-5-THIAZOLYL)METHYL)-N’-METHYL-N”-NITROGUANIDINE, (E)-1-(2-CHLORO-1,3-THIAZOL-5-YL METHYL)-3-METHYL-2-NITROGUANIDINE, CHEBI:39178, 1-((2-chloro-1,3-thiazol-5-yl)methyl)-3-methyl-2-nitroguanidine, (E)-3-((2-chloro-1,3-thiazol-5-yl)methyl)-1-methyl-2-nitroguanidine, (E)-3-[(2-chloro-1,3-thiazol-5-yl)methyl]-1-methyl-2-nitroguanidine, TM444, USEPA/OPP Pesticide Code: 044309, (E)1(2Chloro1,3thiazol5ylmethyl)3methyl2nitroguanidine, Guanidine, N((2chloro5thiazolyl)methyl)N’methylN”nitro, (C(E)), (E)-1-(2-Chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine (clothianidin), 1-((2-chloro-1,3-thiazol-5-yl)methyl)-2-methyl-3-nitroguanidine, 1-[(2-chloro-1,3-thiazol-5-yl)methyl]-2-methyl-3-nitroguanidine, guanidine, n-((2-chloro-5-thiazolyl)methyl)-n’-methyl-n”-nitro-, (c(e))-, guanidine, n-[(2-chloro-5-thiazolyl)methyl]-n’-methyl-n”-nitro-, [c(e)]-, 205510-53-8, (E)-clothianidin, CLOTHIANIDINE, CHEBI:39177, 1-(2-chloro-5-thiazolylmethyl)-3-methyl-2-nitroguanidine, (E)-N-(2-chloro-5-thiazolyl)methyl-N’-methyl-N”-nitroguanidine, (E)-1-[(2-chloro-1,3-thiazol-5-yl)methyl]-3-methyl-2-nitroguanidine, MFCD06200753, Thiamethoxam metabolite, UNII-2V9906ABKQ, SCHEMBL21214, Guanidine, N-[(2-chloro-5-thiazolyl)methyl]-N’-methyl-N”-nitro-, CHEMBL259727, (E)-N’-[(2-chloro-1,3-thiazol-5-yl)methyl]-N-methyl-N”-nitroguanidine, GLXC-15985, KIA88092, MSK20351, Tox21_301191, BDBM50486231, AKOS015900249, AKOS040744778, NCGC00163946-01, NCGC00163946-02, NCGC00163946-03, NCGC00255089-01, Clothianidin 100 microg/mL in Acetonitrile, HY-133167, CAS-210880-92-5, CS-0112847, NS00009180, C18508, F14766, Clothianidin, PESTANAL(R), analytical standard, A814674, Q419355, 1-(2-chlorothiazol-5-yl)-1,2-dimethyl-3-nitro-guanidine, (E)-1-(2-Chloro-1,3-thiazol-5-ylmethyl)-3- methyl-2-nitroguanidine (clothianidin)

Clothianidin is primarily used as a systemic insecticide for crop protection against a wide range of pests in agriculture. It demonstrates particular effectiveness against coleopteran and hemipteran pests in corn, canola, soybeans, and cereals when applied as a seed treatment. Research applications include studies on neonicotinoid mode of action, resistance mechanisms in pest populations, and environmental fate studies. The compound also serves as an important reference standard for analytical method development and residue analysis in food and environmental samples.

Safety and Hazards

GHS Hazard Statements

• H302: Harmful if swallowed [Warning Acute toxicity, oral]
• H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
• H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P264, P270, P273, P301+P317, P330, P391, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Repr. 2 (95.5%)
• STOT SE 1 (95.5%)
• Aquatic Acute 1 (100%)
• Aquatic Chronic 1 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.