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Atomfair Closantel C22H14Cl2I2N2O2 CAS 57808-65-8

Closantel (CAS No. 57808-65-8) is a potent salicylanilide-class anthelmintic agent with the molecular formula C22H14Cl2I2N2O2. Its IUPAC name is N-[5-chloro-4-[(4-chlorophenyl)-cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide . This halogenated compound features dual chlorine and iodine substitutions, conferring broad-spectrum parasiticidal activity. Closantel is supplied as a high-purity (>98%) crystalline solid with characteristic pale yellow to white appearance, suitable for veterinary and research applications. Its unique mechanism involves uncoupling oxidative phosphorylation in parasites, with exceptional plasma protein binding for prolonged systemic action. Store at 2-8°C protected from light. Available in research quantities (100mg to 25g) with HPLC-verified purity certificates.

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Description

Closantel (CAS No. 57808-65-8) is a potent salicylanilide-class anthelmintic agent with the molecular formula C22H14Cl2I2N2O2. Its IUPAC name is N-[5-chloro-4-[(4-chlorophenyl)-cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide. This halogenated compound features dual chlorine and iodine substitutions, conferring broad-spectrum parasiticidal activity. Closantel is supplied as a high-purity (>98%) crystalline solid with characteristic pale yellow to white appearance, suitable for veterinary and research applications. Its unique mechanism involves uncoupling oxidative phosphorylation in parasites, with exceptional plasma protein binding for prolonged systemic action. Store at 2-8°C protected from light. Available in research quantities (100mg to 25g) with HPLC-verified purity certificates.

Properties

  • CAS Number: 57808-65-8
  • Complexity: 652
  • IUPAC Name: N-[5-chloro-4-[(4-chlorophenyl)-cyano-methyl]-2-methyl-phenyl]-2-hydroxy-3,5-diiodo-benzamide
  • InChI: InChI=1S/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30)
  • InChI Key: JMPFSEBWVLAJKM-UHFFFAOYSA-N
  • Exact Mass: 661.85218
  • Molecular Formula: C22H14Cl2I2N2O2
  • Molecular Weight: 663.1
  • SMILES: CC1=CC(=C(C=C1NC(=O)C2=C(C(=CC(=C2)I)I)O)Cl)C(C#N)C3=CC=C(C=C3)Cl
  • Topological: 73.1
  • Monoisotopic Mass: 661.85218
  • Synonyms: Closantel, 57808-65-8, Closantelum, Closantelum [INN-Latin], EINECS 260-967-1, Closantel [USAN:INN:BAN], NSC 335306, NSC-335306, CCRIS 9345, EUL532EI54, DTXSID6040662, R 31,520, CLOSANTEL [INN], CLOSANTEL [MI], CLOSANTEL [USAN], Benzamide, N-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-diiodo-, CLOSANTEL [MART.], R 31520, R-31520, N-(5-Chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide, DTXCID4020662, 5′-Chloro-alpha(sup 4)-(p-chlorophenyl)-alpha(sup 4)-cyano-3,5-diiodo-2′,4′-salicyloxylidide, Benzamide, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodo-, Closantelum (INN-Latin), CLOSANTEL (MART.), (RS)-5′-CHLORO-4′-(4-CHLORO-.ALPHA.-CYANOBENZYL)-3,5-DIIODOSALICYL-O-TOLUIDIDE, Seponver, rac-N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide, rac-N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide, N-(5-chloro-4((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide, CHEBI:77053, (RS)-5′-CHLORO-4′-(4-CHLORO-ALPHA-CYANOBENZYL)-3,5-DIIODOSALICYL-O-TOLUIDIDE, 5′-chloro-alpha(4)-(p-chlorophenyl)-alpha(4)-cyano-3,5-diiodo-2′,4′-salicyloxylidide, 260-967-1, 5′-CHLORO-.ALPHA.(SUP 4)-(P-CHLOROPHENYL)-.ALPHA.(SUP 4)-CYANO-3,5-DIIODO-2′,4′-SALICYLOXYLIDIDE, N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide, CHEMBL12131, MLS001332593, CHEBI:77054, 57808-65-8 (free acid), N-[5-chloro-4-[(4-chlorophenyl)-cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide, N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide, NCGC00166312-01, Closantel 100 microg/mL in Acetonitrile, SMR000857079, C22H14Cl2I2N2O2, CAS-57808-65-8, SR-05000001507, UNII-EUL532EI54, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide; Closantel; Clozantin; NSC 335306; Seponver; Zycloz, MFCD00661151, Closantel (Standard), Closantel (USAN/INN), cid_42574, MLS001332594, SCHEMBL116617, JMPFSEBWVLAJKM-UHFFFAOYSA-N, GLXC-26298, HMS2090A06, HMS2230O20, HMS3652O14, HMS3713O22, HMS5082K14, KUC107298N, Pharmakon1600-01504835, MSK20366, Tox21_112408, AC-277, BDBM50063753, HY-17596R, NSC759819, s4106, STK378904, AKOS005448897, Tox21_112408_1, CCG-213322, CS-3975, FC31089, KS-1255, NSC-759819, NCGC00166312-02, HY-17596, KSC-18-157-1, Closantel 1000 microg/mL in Acetonitrile, NS00014203, ST50868959, SW198946-2, Closantel, PESTANAL(R), analytical standard, D03567, AB00918405_05, AB00918405_06, A831617, Q2560163, SR-05000001507-1, SR-05000001507-3, SR-05000001507-4, BRD-A19952358-001-10-5, BRD-A19952358-001-11-3, BRD-A19952358-001-12-1, BRD-A19952358-236-01-6, 5′-Chloro-.alpha.4-(p-chlorophenyl)-.alpha.4-cyano-3,4′-salicyloxylidide, N-(5-Chloro-4-[(R,S)-(4-chlorophenyl)cyanomethyl]-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide, N-[5-chloranyl-4-[(4-chlorophenyl)-cyano-methyl]-2-methyl-phenyl]-3,5-bis(iodanyl)-2-oxidanyl-benzamide, N-{5-Chloro-4-[(4-chloro-phenyl)-cyano-methyl]-2-methyl-phenyl}-2-hydroxy-3,5-diiodo-benzamide, N-{5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl}(2-hydroxy-3,5-diio dophenyl)carboxamide

Application

Closantel is extensively used in veterinary medicine for controlling liver flukes (Fasciola hepatica) and blood-sucking parasites in livestock. Its high efficacy against multi-drug resistant nematodes makes it valuable for parasitic disease research. The compound’s long half-life enables single-dose treatment regimens. Researchers utilize closantel as a reference standard in LC-MS method development for anthelmintic residue analysis. Recent studies investigate its potential as a chemotherapeutic agent against trypanosome infections.

Safety and Hazards

GHS Hazard Statements

  • H301 (94.4%): Toxic if swallowed [Danger Acute toxicity, oral]
  • H400 (38.9%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
  • H410 (38.9%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]
  • H413 (55.6%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

  • P264, P270, P273, P301+P316, P321, P330, P391, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 3 (94.4%)
  • Aquatic Acute 1 (38.9%)
  • Aquatic Chronic 1 (38.9%)
  • Aquatic Chronic 4 (55.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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