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Atomfair Closantel C22H14Cl2I2N2O2

Description Closantel (CAS No. 57808-65-8) is a potent salicylanilide-class anthelmintic agent with the molecular formula C22H14Cl2I2N2O2. Its IUPAC name is N-[5-chloro-4-[(4-chlorophenyl)-cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide . This halogenated compound features dual chlorine and iodine substitutions, conferring broad-spectrum parasiticidal activity. Closantel is supplied as a high-purity (>98%) crystalline solid with characteristic pale yellow to white appearance, suitable for veterinary and research applications. Its unique mechanism involves uncoupling oxidative phosphorylation in parasites, with exceptional plasma protein binding for prolonged systemic action. Store at 2-8??C protected from light. Available in research quantities (100mg to 25g) with HPLC-verified purity certificates.

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Description

Description

Closantel (CAS No. 57808-65-8) is a potent salicylanilide-class anthelmintic agent with the molecular formula C22H14Cl2I2N2O2. Its IUPAC name is N-[5-chloro-4-[(4-chlorophenyl)-cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide. This halogenated compound features dual chlorine and iodine substitutions, conferring broad-spectrum parasiticidal activity. Closantel is supplied as a high-purity (>98%) crystalline solid with characteristic pale yellow to white appearance, suitable for veterinary and research applications. Its unique mechanism involves uncoupling oxidative phosphorylation in parasites, with exceptional plasma protein binding for prolonged systemic action. Store at 2-8??C protected from light. Available in research quantities (100mg to 25g) with HPLC-verified purity certificates.

  • CAS No: 57808-65-8
  • Molecular Formula: C22H14Cl2I2N2O2
  • Molecular Weight: 663.1
  • Exact Mass: 661.85218
  • Monoisotopic Mass: 661.85218
  • IUPAC Name: N-[5-chloro-4-[(4-chlorophenyl)-cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide
  • SMILES: CC1=CC(=C(C=C1NC(=O)C2=C(C(=CC(=C2)I)I)O)Cl)C(C#N)C3=CC=C(C=C3)Cl
  • Synonyms: Closantel, 57808-65-8, Closantelum, Closantelum [INN-Latin], EINECS 260-967-1

Application

Closantel is extensively used in veterinary medicine for controlling liver flukes (Fasciola hepatica) and blood-sucking parasites in livestock. Its high efficacy against multi-drug resistant nematodes makes it valuable for parasitic disease research. The compound’s long half-life enables single-dose treatment regimens. Researchers utilize closantel as a reference standard in LC-MS method development for anthelmintic residue analysis. Recent studies investigate its potential as a chemotherapeutic agent against trypanosome infections.

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