Description

(Chloromethyl)pentafluorobenzene (CAS No. 653-35-0) is a highly fluorinated aromatic compound with the molecular formula C₇H₂ClF₅. This specialized chemical, also known as 2,3,4,5,6-pentafluorobenzyl chloride, features a chloromethyl group attached to a pentafluorobenzene ring, making it a valuable intermediate in organic synthesis and pharmaceutical applications. Its high purity and stability ensure reliable performance in demanding reactions, such as nucleophilic substitutions and cross-coupling reactions. Ideal for researchers and scientists working in fluorinated compound synthesis, this product is rigorously tested for quality and consistency. Available in various quantities to suit laboratory-scale and industrial needs.

Properties

• CAS Number: 653-35-0
• Complexity: 162
• IUPAC Name: 1-(chloromethyl)-2,3,4,5,6-pentafluoro-benzene
• InChI: InChI=1S/C7H2ClF5/c8-1-2-3(9)5(11)7(13)6(12)4(2)10/h1H2
• InChI Key: ZLNVRXFZTPRLIK-UHFFFAOYSA-N
• Exact Mass: 215.9765186
• Molecular Formula: C7H2ClF5
• Molecular Weight: 216.53
• SMILES: C(C1=C(C(=C(C(=C1F)F)F)F)F)Cl
• Monoisotopic Mass: 215.9765186
• Synonyms: 653-35-0, 2,3,4,5,6-pentafluorobenzyl chloride, (Chloromethyl)pentafluorobenzene, J3AMF5UR8V, EINECS 211-501-0, DTXSID90215646, CHLOROMETHYLPENTAFLUOROBENZENE, BENZENE, 1-(CHLOROMETHYL)-2,3,4,5,6-PENTAFLUORO-, DTXCID20138137, 211-501-0, 1-(Chloromethyl)-2,3,4,5,6-pentafluorobenzene, 2,3,4,5,6-Pentafluorobenzylchloride, Benzene, (chloromethyl)pentafluoro-, .alpha.-Chloro-2,3,4,5,6-pentafluorotoluene, MFCD00040864, UNII-J3AMF5UR8V, SCHEMBL2074171, BBL011093, CK2009, SBB070796, STK802324, AKOS005622567, AC-9751, AS-45843, NS00042707, EN300-226053, 4-(chloromethyl)-1,2,3,5,6-pentafluorobenzene, 1-(Chloromethyl)-2,3,4,5,6-pentafluorobenzene #, Benzene, 1-(chloromethyl)2,3,4,5,6-pentafluoro-

Application

(Chloromethyl)pentafluorobenzene is widely used as a key building block in the synthesis of fluorinated pharmaceuticals, agrochemicals, and liquid crystals. Its reactive chloromethyl group enables facile functionalization, making it valuable for introducing pentafluorophenyl moieties into target molecules. This compound is also employed in the preparation of advanced materials and as a derivatization agent in analytical chemistry for enhancing detection sensitivity.

Safety and Hazards

GHS Hazard Statements

• H227 (14.3%): Combustible liquid [Warning Flammable liquids]
• H302 (85.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (85.7%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H314 (85.7%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (14.3%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (14.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (85.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (14.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P370+P378, P403, P403+P233, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 4 (14.3%)
• Acute Tox. 4 (85.7%)
• Acute Tox. 4 (85.7%)
• Skin Corr. 1B (85.7%)
• Skin Irrit. 2 (14.3%)
• Eye Irrit. 2 (14.3%)
• Acute Tox. 4 (85.7%)
• STOT SE 3 (14.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.