Description

Chloroisopropylmagnesium (CAS No. 1068-55-9) is a highly reactive Grignard reagent with the molecular formula C₃H₇ClMg. This organomagnesium compound is widely utilized in synthetic organic chemistry for nucleophilic addition reactions, coupling processes, and the formation of carbon-carbon bonds. Typically supplied as a solution in ethereal solvents such as diethyl ether or tetrahydrofuran (THF), it offers consistent reactivity and high purity, making it indispensable for laboratory and industrial applications. Chloroisopropylmagnesium is moisture- and air-sensitive, requiring handling under inert atmospheres (e.g., nitrogen or argon) to maintain stability. Ideal for researchers and chemists seeking precision in complex synthesis, this reagent is rigorously tested to meet stringent quality standards.

Properties

• CAS Number: 1068-55-9
• Complexity: 6.9
• IUPAC Name: magnesium;propane;chloride
• InChI: InChI=1S/C3H7.ClH.Mg/c1-3-2;;/h3H,1-2H3;1H;/q-1;;+2/p-1
• InChI Key: IUYHWZFSGMZEOG-UHFFFAOYSA-M
• Exact Mass: 102.0086696
• Molecular Formula: C3H7ClMg
• Molecular Weight: 102.84
• SMILES: C[CH-]C.[Mg+2].[Cl-]
• Monoisotopic Mass: 102.0086696
• Physical Description: Liquid
• Synonyms: Isopropylmagnesium Chloride, 1068-55-9, Magnesium, chloro(1-methylethyl)-, Chloro(1-methylethyl)magnesium, Chloroisopropylmagnesium, 2-Propylmagnesium chloride, MN8G5FEJ5J, EINECS 213-947-1, Chloro(propan-2-yl)magnesium, DTXSID6061444, EC 213-947-1, MAGNESIUM, CHLOROISOPROPYL-, Magnesium, chloro(1methylethyl), DTXCID7033028, 213-947-1, isopropyl magnesium chloride, i-PrMgCl, MFCD00000466, Magnesium, chloroisopropyl- (7CI,8CI); 2-Propylmagnesium chloride; Chloro(propan-2-yl)magnesium; Chloroisopropylmagnesium, i-propylmagnesium chloride, iPrMgCl, iPr-MgCl, i-propylmagnesiumchloride, isopropylmagnesiumchloride, isopropylmagnesium chlorid, isopropymagnesium chloride, Isopropylmagnesium chloride, 2.0 M in THF, UNII-MN8G5FEJ5J, Chloro(isopropyl)magnesium, Chloro-isopropyl-magnesium, isopropyl magnesiumchloride, isopropylmagnesium-chloride, i-propyl magnesium chloride, iso-Propylmagnesium chloride, isopropyl-magnesium chloride, 2-propyl magnesium chloride, SCHEMBL4892, Isopropylmagnesium chloride, 1.0 M in 2-MeTHF, iso-propyl magnesium chloride, iso-propyl-magnesium chloride, iso-propyl-magnesium-chloride, GPIBKUJXKCEZOH-UHFFFAOYSA-M, AKOS015909147, Isopropyl magnesium chloride 2M in THF, Isopropylmagnesium chloride, 1M in MeTHF, i-Propylmagnesium chloride, 2-3M in ether, DB-370623, NS00079517, Isopropyl magnesium chloride 2M in diethyl ether, Isopropylmagnesium Chloride (13% in Ethyl Ether, ca. 1mol/L), Isopropylmagnesium Chloride (ca. 13% in Ethyl Ether, ca. 1mol/L), Isopropylmagnesium Chloride (ca. 11% in Tetrahydrofuran, ca. 1mol/L)

Application

Chloroisopropylmagnesium is primarily used as a Grignard reagent in organic synthesis for nucleophilic additions to carbonyl compounds, enabling the formation of alcohols, ketones, and carboxylic acids. It is also employed in cross-coupling reactions, such as Kumada couplings, to construct carbon-carbon bonds in pharmaceuticals and agrochemicals. Additionally, this reagent serves as a strong base for deprotonation reactions and as a precursor for other organometallic compounds.

Safety and Hazards

GHS Hazard Statements

• H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H260 (50%): In contact with water releases flammable gases which may ignite spontaneously [Danger Substances and mixtures which in contact with water, emit flammable gases]
• H261 (50%): In contact with water releases flammable gas [Danger Substances and mixtures which in contact with water, emit flammable gases]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (50%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H336 (50%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]
• H351 (50%): Suspected of causing cancer [Warning Carcinogenicity]

Precautionary Statements

• P203, P210, P223, P231+P232, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P335+P334, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P363, P370+P378, P402+P404, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (100%)
• Water-react. 1 (50%)
• Water-react. 2 (50%)
• Skin Corr. 1B (100%)
• Eye Dam. 1 (50%)
• STOT SE 3 (100%)
• STOT SE 3 (50%)
• Carc. 2 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.