Description

Chlorodifluoroacetic Acid (CAS No. 76-04-0) is a highly specialized fluorinated organic compound with the molecular formula C₂HClF₂O₂ and IUPAC name 2-chloro-2,2-difluoroacetic acid. This reagent is characterized by its strong acidic properties and unique reactivity due to the presence of both chlorine and fluorine substituents on the alpha carbon. It is commonly utilized in synthetic organic chemistry, particularly in the preparation of fluorinated building blocks and as a precursor for pharmaceuticals, agrochemicals, and advanced materials. Available in high-purity grades, our Chlorodifluoroacetic Acid is rigorously tested for consistency, ensuring optimal performance in demanding applications. Proper handling under inert conditions is recommended due to its corrosive nature.

Properties

• CAS Number: 76-04-0
• Complexity: 91.7
• IUPAC Name: 2-chloro-2,2-difluoro-acetic acid
• InChI: InChI=1S/C2HClF2O2/c3-2(4,5)1(6)7/h(H,6,7)
• InChI Key: OAWAZQITIZDJRB-UHFFFAOYSA-N
• Exact Mass: 129.9633133
• Molecular Formula: C2HClF2O2
• Molecular Weight: 130.48
• SMILES: C(=O)(C(F)(F)Cl)O
• Topological: 37.3
• Monoisotopic Mass: 129.9633133
• Physical Description: Clear colorless to light brown liquid; mp = 20 deg C;
• Synonyms: Chlorodifluoroacetic acid, 76-04-0, EINECS 200-928-8, NSC 60298, AI3-52628, DTXSID8058792, Acetic acid, chlorodifluoro, DTXCID0047824, Acetic acid, 2chloro2,2difluoro, 200-928-8, oawazqitizdjrb-uhfffaoysa-n, un3265, Acetic acid, chlorodifluoro-, 2-chloro-2,2-difluoroacetic acid, difluorochloroacetic acid, NSC-60298, Acetic acid, 2-chloro-2,2-difluoro-, C2HClF2O2, Chlorodifluoroaceticacid, chloro(difluoro)acetic acid, 2-chloro-2,2-difluoro-acetic acid, MFCD00004176, CDFA, chlorodifluoro acetic acid, CPP4X8QU8R, PFCA-Cl; C2HClF2O2, SCHEMBL132463, SCHEMBL245872, Chlorodifluoroacetic acid, 98%, BCP24417, NSC60298, STR00299, AKOS000119358, CS-W001107, DB-056017, C0990, NS00041048, EN300-20290, S12286, F2191-0221, Z1270446583

Application

Chlorodifluoroacetic Acid is widely employed as a versatile fluorinating agent in organic synthesis, enabling the introduction of difluoromethyl groups into target molecules. It serves as a key intermediate in the production of pharmaceuticals, including protease inhibitors and other bioactive compounds. Researchers also utilize it in the synthesis of agrochemicals and specialty materials requiring fluorinated motifs.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (38.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Precautionary Statements

• P260, P264, P264+P265, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)
• Eye Dam. 1 (38.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.