Description

Chlorantraniliprole (CAS No. 500008-45-7) is a highly effective anthranilic diamide insecticide with the molecular formula C₁₈H₁₄BrCl₂N₅O₂. Its IUPAC name is 5-bromo-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloropyridin-2-yl)pyrazole-3-carboxamide. This compound is a selective activator of the ryanodine receptor (RyR), disrupting calcium regulation in insect muscles and leading to paralysis and death. Chlorantraniliprole exhibits exceptional activity against a broad spectrum of lepidopteran pests while demonstrating low mammalian toxicity and minimal environmental impact. Its unique mode of action makes it a valuable tool in integrated pest management (IPM) programs and resistance management strategies. Available in high-purity formulations suitable for research, agricultural applications, and formulation development.

Properties

• CAS Number: 500008-45-7
• Complexity: 586
• IUPAC Name: 5-bromo-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloro-2-pyridyl)pyrazole-3-carboxamide
• InChI: InChI=1S/C18H14BrCl2N5O2/c1-9-6-10(20)7-11(17(27)22-2)15(9)24-18(28)13-8-14(19)25-26(13)16-12(21)4-3-5-23-16/h3-8H,1-2H3,(H,22,27)(H,24,28)
• InChI Key: PSOVNZZNOMJUBI-UHFFFAOYSA-N
• LogP: log Kow = 2.76
• Exact Mass: 480.97079
• Molecular Formula: C18H14BrCl2N5O2
• Molecular Weight: 483.1
• SMILES: CC1=CC(=CC(=C1NC(=O)C2=CC(=NN2C3=C(C=CC=N3)Cl)Br)C(=O)NC)Cl
• Topological: 88.9
• Monoisotopic Mass: 480.97079
• Color/Form: Fine, crystalline, off-white powder
• Melting Point: 208-210 °C
• Solubility: Solubility in acetone 3.4, acetonitrile 0.71, dichloromethane 2.48, ethyl acetate 1.14, methanol 1.71
• Density: 1.1589 (95.9%); 1.507 (99.2%) at 20 °C
• Stability/Shelf Life: Stable at normal temperatures and storage conditions. /DuPont Dermacor X-100 Seed Treatment/
• Dissociation Constants: pKa = 10.88
• Synonyms: Chlorantraniliprole, 500008-45-7, DPX-E2Y45, chlorantranilipole, Rynaxpyr, Rynaxypyr, UNII-622AK9DH9G, 622AK9DH9G, CHEBI:67113, HSDB 7877, DTXSID2044345, 3-bromo-4-chloro-1-(3-chloro-2-pyridyl)-2′-methyl-6-(methylcarbamoyl)pyrazole-5’carboxanilide, 3-bromo-N-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide, 3-bromo-4′-chloro-1-(3-chloro-2-pyridyl)-2′-methyl-6′-(methylcarbamoyl)pyrazole-5-carboxanilide, 3-bromo-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide, DTXCID0024345, USEPA/OPP Pesticide Code: 090100, 1H-Pyrazole-5-carboxamide, 3-bromo-N-, 3-bromo-4-chloro-1-(3-chloro-2-pyridyl)-2?-methyl-6-(methylcarbamoyl)pyrazole-5-carboxanilide, CHLOANTRANILIPROLE, Chlorantraniliprole [ISO], CHEMBL399318, 5-bromo-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloropyridin-2-yl)pyrazole-3-carboxamide, 3-bromo-N-(4-chloro-2-methyl-6-((methylamino)carbonyl)phenyl)-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide, 3-Bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide, 3-bromo-N-{4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl}-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide, 5-bromanyl-N-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide, Coragen, F0U, MFCD11840831, SCHEMBL29551, Chlorantraniliprole (Standard), CHLORANTRANILIPROLE [MI], GLXC-15702, BCP12712, DKI 0001, MSK20310, BDBM50222771, AKOS015895788, DS-9084, HY-112820R, MSK20310-1000M, FC171099, DB-071077, HY-112820, CS-0065743, NS00002799, C18454, Chlorantraniliprole 100 microg/mL in Acetonitrile, Chlorantraniliprole Solution in Methanol, 1000ug/mL, Q2301181, Chlorantraniliprole, PESTANAL(R), analytical standard, 3-bromo-N-[4-chloro-2-methyl-6- [(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide, 3-bromo-N-[4-chloro-2-methyl-6-[(methyl-amino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide, 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)-carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide, 3-Bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3- chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide, Pesticide4_Chlorantraniliprole_C18H14BrCl2N5O2_3-Bromo-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

Application

Chlorantraniliprole is widely used in agricultural pest control, particularly against lepidopteran larvae such as diamondback moth, corn borer, and cotton bollworm. It is applied as a foliar spray or soil treatment in crops including corn, soybeans, fruits, and vegetables. The compound’s systemic activity provides long-lasting protection by translaminar movement within plant tissues. Its selective toxicity makes it compatible with beneficial insects, supporting sustainable farming practices.

Safety and Hazards

GHS Hazard Statements

• H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]
• H351: Suspected of causing cancer [Warning Carcinogenicity]
• H360: May damage fertility or the unborn child [Danger Reproductive toxicity]
• H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
• H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]
• H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P203, P260, P261, P271, P273, P280, P304+P340, P318, P319, P391, P403+P233, P405, and P501

Hazard Classes and Categories

• Eye Irrit. 2 (39.4%)
• STOT SE 3 (39.4%)
• Aquatic Acute 1 (60.6%)
• Aquatic Chronic 1 (60.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.