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Atomfair Butanoic acid, 4,4-difluoro-3-oxo-, ethyl ester Ethyl difluoroacetoacetate C6H8F2O3

Description Ethyl 4,4-difluoro-3-oxobutanoate (CAS No. 352-24-9) is a high-purity fluorinated organic compound with the molecular formula C6H8F2O3. This ester derivative of difluoroacetoacetic acid is a versatile building block in synthetic organic chemistry, particularly for the preparation of fluorinated heterocycles and pharmaceuticals. The compound features a reactive ??-ketoester moiety with two fluorine atoms at the 4-position, enabling unique reactivity patterns in nucleophilic and electrophilic transformations. With a molecular weight of 166.12 g/mol, this liquid reagent offers excellent solubility in common organic solvents like ethanol, acetone, and dichloromethane. Our product is rigorously tested by GC-MS and1H/19F NMR to ensure >98% purity, making…

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Description

Description

Ethyl 4,4-difluoro-3-oxobutanoate (CAS No. 352-24-9) is a high-purity fluorinated organic compound with the molecular formula C6H8F2O3. This ester derivative of difluoroacetoacetic acid is a versatile building block in synthetic organic chemistry, particularly for the preparation of fluorinated heterocycles and pharmaceuticals. The compound features a reactive ??-ketoester moiety with two fluorine atoms at the 4-position, enabling unique reactivity patterns in nucleophilic and electrophilic transformations. With a molecular weight of 166.12 g/mol, this liquid reagent offers excellent solubility in common organic solvents like ethanol, acetone, and dichloromethane. Our product is rigorously tested by GC-MS and 1H/19F NMR to ensure >98% purity, making it ideal for sensitive applications in medicinal chemistry and material science research. Available in amber glass bottles under inert atmosphere to guarantee stability.

  • CAS No: 352-24-9
  • Molecular Formula: C6H8F2O3
  • Molecular Weight: 166.12
  • Exact Mass: 166.04415044
  • Monoisotopic Mass: 166.04415044
  • IUPAC Name: ethyl 4,4-difluoro-3-oxobutanoate
  • SMILES: CCOC(=O)CC(=O)C(F)F
  • Synonyms: 352-24-9, Ethyl 4,4-difluoroacetoacetate, Ethyl difluoroacetoacetate, Butanoic acid, 4,4-difluoro-3-oxo-, ethyl ester, EINECS 206-519-0

Application

Ethyl 4,4-difluoro-3-oxobutanoate serves as a key fluorinated synthon in pharmaceutical intermediate synthesis, particularly for introducing difluoromethyl groups into target molecules. The compound’s ??-ketoester functionality enables its use in Claisen condensations and Michael additions for constructing complex fluorinated architectures. Researchers employ this reagent in the development of protease inhibitors and other bioactive molecules where fluorine substitution modulates metabolic stability. In material science, it acts as a precursor for fluorinated polymers with enhanced thermal and chemical resistance.

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