Description

Butamben (CAS 94-25-7), also known as butyl 4-aminobenzoate, is a high-purity organic compound with the molecular formula C₁₁H₁₅NO₂. This ester of 4-aminobenzoic acid is widely utilized in pharmaceutical and research applications due to its local anesthetic properties. Our Butamben is synthesized under strict quality control to ensure ≥98% purity (HPLC), with comprehensive analytical data including ¹H NMR, FT-IR, and mass spectrometry available upon request. The product is supplied as a white crystalline powder with a melting point range of 57-60°C, packaged under nitrogen atmosphere to ensure stability. Suitable for use in formulation studies, receptor binding assays, and as a reference standard in analytical applications.

Key Specifications:
• Purity: ≥98% (HPLC)
• Molecular Weight: 193.24 g/mol
• Storage: 2-8°C in airtight container
• Solubility: Soluble in ethanol, DMSO; slightly soluble in water
• Hazard Codes: Xi (Irritant)

Properties

• CAS Number: 94-25-7
• Complexity: 174
• IUPAC Name: butyl 4-aminobenzoate
• InChI: InChI=1S/C11H15NO2/c1-2-3-8-14-11(13)9-4-6-10(12)7-5-9/h4-7H,2-3,8,12H2,1H3
• InChI Key: IUWVALYLNVXWKX-UHFFFAOYSA-N
• Exact Mass: 193.110278721
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.24
• SMILES: CCCCOC(=O)C1=CC=C(C=C1)N
• Topological: 52.3
• Monoisotopic Mass: 193.110278721
• Physical Description: N-butyl-p-aminobenzoate is a yellow powder. Insoluble in water.
• Color/Form: Crystals from alc
• Odor: Odorless
• Taste: Tasteless
• Boiling Point: 343 to 345 °F at 8 mmHg
• Melting Point: 136 °F
• Solubility: Insoluble
• Vapor Pressure: 0.000299 [mmHg]
• Dissociation Constants: 2.472
• Synonyms: Butyl 4-aminobenzoate, butamben, 94-25-7, Butesin, Butyl aminobenzoate, Butylcaine, Butesine, Butoform, Planoform, Scuroform, Scuroforme, BUTYL P-AMINOBENZOATE, 4-(Butoxycarbonyl)aniline, Butyl keloform, Benzoic acid, 4-amino-, butyl ester, N-Butyl p-aminobenzoate, p-Aminobenzoic acid butyl ester, 4-Aminobenzoic acid butyl ester, Butyl PABA, n-Butyl-p-aminobenzoate, Benzoic acid, p-amino-, butyl ester, Butamben [USAN], Butesin (TN), NSC-128464, CHEBI:3231, DTXSID7022417, EFW857872Q, BUTAMBEN [HSDB], BUTAMBEN [MI], BUTAMBEN [VANDF], BUTAMBEN [USP-RS], DTXCID102417, BUTAMBEN [USP MONOGRAPH], p-Aminobenzoic acid n-butyl ester, ABBOTT-34842 FREE BASE, BUTYL AMINOBENZOATE [MART.], BUTYL AMINOBENZOATE [WHO-DD], butanylcaine, zyljectin, BUTAMBEN (USP-RS), BUTAMBEN (USP MONOGRAPH), BUTYL AMINOBENZOATE (MART.), Butyl paminobenzoate, Butyl 4aminobenzoate, nButyl paminobenzoate, butyl para-aminobenzoate, 4(Butoxycarbonyl)aniline, BUTYL PABA [INCI], pAminobenzoic acid butyl ester, 4Aminobenzoic acid butyl ester, Butylester kyseliny paminobenzoove, Benzoic acid, pamino, butyl ester, Benzoic acid, 4amino, butyl ester, 202-317-1, 4-Aminobenzoic Acid n-Butyl Ester, MFCD00017112, NSC 128464, 4-amino butylbenzoate, p-Aminobenzoic acid, butyl ester, Butylester kyseliny p-aminobenzoove, MLS000028721, NSC128464, CAS-94-25-7, NCGC00016353-03, SMR000059139, Butyl 4-?Aminobenzoate(Butamben), Butsein, CCRIS 5891, HSDB 4245, Butamben [USAN:USP], SR-01000721933, EINECS 202-317-1, 4-Aminobenzoic acid butyl, BRN 1211465, Butoforme, UNII-EFW857872Q, AI3-02284, Butylester kyseliny p-aminobenzoove [Czech], Butamben (USP), Prestwick_994, Butamben (Standard), butyl -4-aminobenzoate, Spectrum_000025, n-butyl 4-aminobenzoate, Opera_ID_633, SpecPlus_000829, Prestwick0_000761, Prestwick1_000761, Prestwick2_000761, Prestwick3_000761, Spectrum2_000850, Spectrum3_001848, Spectrum4_000832, Spectrum5_001496, WLN: ZR DVO4, aniline, 4-butoxycarbonyl-, SCHEMBL81735, BSPBio_000802, BSPBio_003236, KBioGR_001403, KBioSS_000385, MLS002303044, BIDD:ER0674, DivK1c_000838, DivK1c_006925, SPECTRUM1500767, SPBio_000839, SPBio_002741, BPBio1_000884, CHEMBL127516, SCHEMBL8393239, HMS502J20, HY-B1430R, KBio1_000838, KBio1_001869, KBio2_000385, KBio2_002953, KBio2_005521, KBio3_002736, NINDS_000838, HMS1570I04, HMS1921G20, HMS2092K06, HMS2097I04, HMS2234M07, HMS3372C17, HMS3714I04, HMS3885N08, HMS5083L15, Pharmakon1600-01500767, HY-B1430, Tox21_110392, Tox21_200378, CCG-40317, NSC757433, s4583, SBB007542, STL169355, AKOS000119787, Tox21_110392_1, CS-4822, DB11148, FA45227, NSC-757433, IDI1_000838, NCGC00016353-01, NCGC00016353-02, NCGC00016353-04, NCGC00016353-05, NCGC00016353-06, NCGC00016353-08, NCGC00091154-01, NCGC00091154-02, NCGC00091154-03, NCGC00091154-04, NCGC00257932-01, AC-13349, DS-13802, ST059627, SY051932, SBI-0051887.P002, DB-029553, A0270, AB00052407, NS00004238, EN300-17938, C07875, D00730, W16695, AB00052407_12, AE-641/05573061, Q5002348, SR-01000721933-2, SR-01000721933-3, BRD-K27217864-001-04-1, BRD-K27217864-001-05-8, BRD-K27217864-001-15-7, BRD-K27217864-001-22-3, Z57126994, F2190-0449, Butamben, United States Pharmacopeia (USP) Reference Standard

Application

Butamben is primarily employed as a local anesthetic in topical pharmaceutical formulations, particularly in combination with other anesthetic agents for prolonged dermal analgesia. In research settings, it serves as a valuable tool for studying voltage-gated sodium channel interactions due to its mechanism of action as a sodium channel blocker. The compound is also utilized in dermatological preparations for treating minor skin irritations and as a reference standard in analytical method development for pharmaceutical quality control.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (95.3%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P272, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Skin Sens. 1 (95.3%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (95.3%)

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