Description

Bromouracil (CAS 51-20-7) is a halogenated uracil analog with the molecular formula C₄H₃BrN₂O₂ and IUPAC name 5-bromo-1H-pyrimidine-2,4-dione. This white to off-white crystalline powder is a potent thymine analog widely used in biochemical and molecular biology research. With a molecular weight of 191.98 g/mol, Bromouracil exhibits high purity (≥98%) and is soluble in water, dimethyl sulfoxide (DMSO), and alkaline solutions. It serves as a mutagenic base analog that incorporates into DNA in place of thymine, making it invaluable for studying DNA replication, mutagenesis, and nucleic acid metabolism. Our product is rigorously tested for quality and stability, ensuring optimal performance in your laboratory applications. Available in various packaging options to suit your research needs.

Properties

• CAS Number: 51-20-7
• Complexity: 199
• IUPAC Name: 5-bromo-1H-pyrimidine-2,4-dione
• InChI: InChI=1S/C4H3BrN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
• InChI Key: LQLQRFGHAALLLE-UHFFFAOYSA-N
• LogP: log Kow = -0.21
• Exact Mass: 189.93779
• Molecular Formula: C4H3BrN2O2
• Molecular Weight: 190.98
• SMILES: C1=C(C(=O)NC(=O)N1)Br
• Topological: 58.2
• Monoisotopic Mass: 189.93779
• Physical Description: 5-bromouracil is a white powder.
• Color/Form: Prisms from water
• Melting Point: 590 °F
• Solubility: less than 1 mg/mL at 75 °F
• Vapor Pressure: 0.00000023 [mmHg]
• Synonyms: 5-Bromouracil, BROMOURACIL, 5-Bromo-2,4-dihydroxypyrimidine, 2,4(1H,3H)-Pyrimidinedione, 5-bromo-, C4H3BrN2O2, CHEBI:20552, EINECS 200-084-0, NSC 19940, 4HK400G5UO, 5-bromo-1,2,3,4-tetrahydropyrimidine-2,4-dione, AI3-25471, HSDB 7495, NSC-19940, 1,2,3,4-tetrahydro-5-bromo-2,4-pyrimidinedione, 5-BROMOURACIL [MI], DTXSID2058758, 2,4-Pyrimidinedione, 1,2,3,4-tetrahydro-5-bromo, 5 bromouracil, Uracil, 5bromo, 5Bromo2,4pyrimidinedione, Uracil, 5-bromo-(VAN), 5Bromo2,4dihydroxypyrimidine, 5-Bromo-2,4-pyrimidinediol, DTXCID2040945, 5Bromo2,4(1H,3H)pyrimidinedione, Uracil, 5-bromo-(VAN) (8CI), 5-BROMO-2,4-PYRIMIDINEDIONE, 2,4(1H,3H)Pyrimidinedione, 5bromo, lqlqrfghaallle-uhfffaoysa-n, 51-20-7, 5-Bromo-1H-pyrimidine-2,4-dione, 5-bromopyrimidine-2,4(1H,3H)-dione, 5-Bromo-2,4(1H,3H)-pyrimidinedione, Uracil, 5-bromo-, 5-bromopyrimidine-2,4-diol, MFCD00006017, 5-bromo-1,3-dihydropyrimidine-2,4-dione, 5-BrU, UNII-4HK400G5UO, Uracil, 5-bromo- (VAN), 5-BU, 5-bromo-uracil, Bromhydroxypyrimidinon, 5-Bromouracil, 98%, Epitope ID:138109, 5-Brom-6-hydroxypyrimidinon, 5-Bromouracil (5-Bromo-2,4-dihydroxypyrimidine), SCHEMBL29805, CHEMBL144730, SCHEMBL3148463, SCHEMBL8740942, SCHEMBL11005103, 2,3H)-Pyrimidinedione, 5-bromo-, NSC19940, STR01501, BBL013052, CCG-46723, SBB003643, STK301806, STL451516, pyrimidine, 5-bromo-2,4-dihydroxy-, AKOS001448866, AKOS009097562, AB00570, AC-3034, CS-W001982, FB04498, HY-W001982, BP-12090, PD211515, SY003631, 5-Bromo-2,4(1H,3H)-pyrimidinedione #, DB-002591, pyrimidine-2,4(1H,3H)-dione, 5-bromo-, B0665, EU-0035288, NS00032236, ST45022283, EN300-51230, AC-907/25014019, Q238477, SR-01000636400-1, F3096-1702, Z275128628, InChI=1/C4H3BrN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9, URB

Application

Bromouracil is primarily used as a thymine analog in molecular biology research to study DNA replication and mutagenesis. It is incorporated into DNA in place of thymine, leading to base-pairing errors and subsequent mutations. Researchers utilize Bromouracil to investigate nucleic acid metabolism, DNA repair mechanisms, and the effects of base analogs on genetic stability. Additionally, it serves as a tool in virology studies to induce mutations in viral genomes. Its mutagenic properties make it valuable for understanding carcinogenesis and developing novel therapeutic strategies.

Safety and Hazards

GHS Hazard Statements

• H302 (90.7%): Harmful if swallowed [Warning Acute toxicity, oral]

Precautionary Statements

• P264, P270, P301+P317, P330, and P501

Hazard Classes and Categories

• Acute Tox. 4 (90.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.