Description

(Bromodifluoromethyl)trimethylsilane (CAS No. 115262-01-6) is a highly versatile organosilicon compound with the molecular formula C₄H₉BrF₂Si. This reagent is widely used in organic synthesis, particularly for introducing the difluoromethyl group into target molecules. Its IUPAC name, [bromo(difluoromethyl)]-trimethylsilane, reflects its precise chemical structure. The compound is a clear, colorless to pale yellow liquid with a characteristic odor, and it should be stored under inert conditions due to its sensitivity to moisture and air. With a purity of ≥95%, it is ideal for research and industrial applications in pharmaceuticals, agrochemicals, and materials science. Proper handling with PPE is recommended.

Properties

• CAS Number: 115262-01-6
• Complexity: 86.5
• IUPAC Name: [bromo(difluoro)methyl]-trimethyl-silane
• InChI: InChI=1S/C4H9BrF2Si/c1-8(2,3)4(5,6)7/h1-3H3
• InChI Key: WDZVWBWAUSUTTO-UHFFFAOYSA-N
• Exact Mass: 201.96250
• Molecular Formula: C4H9BrF2Si
• Molecular Weight: 203.10
• SMILES: C[Si](C)(C)C(F)(F)Br
• Monoisotopic Mass: 201.96250
• Synonyms: 115262-01-6, (bromodifluoromethyl)trimethylsilane, 806-938-4, TriMethyl(broModifluoroMethyl)silane, Silane, (bromodifluoromethyl)trimethyl-, [Bromo(difluoro)methyl]trimethylsilane, [bromo(difluoro)methyl]-trimethylsilane, MFCD18641931, [bromo(difluoro)methyl](trimethyl)silane, C4H9BrF2Si, SCHEMBL17496583, Bromodifluoro(trimethylsilyl)methane, BBL103059, STL556868, AKOS015913770, PB39673, (Bromodifluoromethyl)trimethylsilane, 98%, MS-20546, SY047583, SY281463, DB-321820, B4325, CS-0108785, A11751, EN300-141359

Application

(Bromodifluoromethyl)trimethylsilane is a key reagent for nucleophilic difluoromethylation reactions in organic synthesis. It is commonly employed in the preparation of difluoromethylated aromatic and heteroaromatic compounds, which are valuable in medicinal chemistry. The compound also serves as a building block for advanced materials with unique electronic properties. Its reactivity with various electrophiles makes it useful in cross-coupling and C–H functionalization reactions.

Safety and Hazards

GHS Hazard Statements

• H225 (37.5%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H226 (62.5%): Flammable liquid and vapor [Warning Flammable liquids]
• H315 (87.5%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (87.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (87.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (37.5%)
• Flam. Liq. 3 (62.5%)
• Skin Irrit. 2 (87.5%)
• Eye Irrit. 2 (87.5%)
• STOT SE 3 (87.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.