Description

Bromodifluoroacetyl chloride (CAS 3832-48-2) is a highly reactive and versatile organofluorine compound with the molecular formula C₂BrClF₂O. This acyl chloride derivative is characterized by its 2-bromo-2,2-difluoroacetyl chloride structure, making it a valuable intermediate in synthetic organic and medicinal chemistry. The compound is typically supplied as a clear to pale yellow liquid with a pungent odor, requiring careful handling under inert conditions due to its moisture sensitivity.

With a purity of ≥95% (GC), our product is ideal for nucleophilic substitution reactions, Friedel-Crafts acylation, and heterocycle synthesis. Its unique combination of bromine and fluorine substituents enables selective functionalization in complex molecular architectures. The product is packaged in amber glass bottles under nitrogen atmosphere to ensure stability, with available quantities ranging from 1g to 1kg scales.

Key applications include pharmaceutical intermediate synthesis, agrochemical production, and materials science research. Spectral data (¹H NMR, ¹³C NMR, FT-IR) and MSDS are available upon request. Store at 2-8°C in a well-ventilated area, away from bases and nucleophiles.

Properties

• CAS Number: 3832-48-2
• Complexity: 93.7
• IUPAC Name: 2-bromo-2,2-difluoro-acetyl chloride
• InChI: InChI=1S/C2BrClF2O/c3-2(5,6)1(4)7
• InChI Key: LYJKGSALBRSKNL-UHFFFAOYSA-N
• Exact Mass: 191.87891
• Molecular Formula: C2BrClF2O
• Molecular Weight: 193.37
• SMILES: C(=O)(C(F)(F)Br)Cl
• Topological: 17.1
• Monoisotopic Mass: 191.87891
• Synonyms: Bromodifluoroacetyl chloride, 3832-48-2, 2-bromo-2,2-difluoroacetyl chloride, DTXSID90334487, DTXCID00285577, 2-Bromo-2,2-difluoro-ethanoyl chloride, 671-811-0, bromo(difluoro)acetyl chloride, Bromodifluoroacetylchloride, MFCD00069081, bromodifluoroacetic chloride, SCHEMBL1161314, AKOS005173358, 2-Bromo-2,2-difluoroethanoyl chloride, FS-4964, DB-022977, NS00123354, 2-bromanyl-2,2-bis(fluoranyl)ethanoyl chloride, EN300-7268228, A824108, Q4973729

Application

Bromodifluoroacetyl chloride serves as a key building block for introducing difluoromethyl and bromodifluoromethyl groups into target molecules. It is extensively used in the synthesis of bioactive compounds, particularly in pharmaceutical research for protease inhibitors and kinase modulators. The compound’s reactivity enables efficient preparation of α,α-difluoro-β-ketoesters and heteroaromatic derivatives. Its dual halogen functionality allows sequential substitution reactions in medicinal chemistry applications.

Safety and Hazards

GHS Hazard Statements

• H226 (90.9%): Flammable liquid and vapor [Warning Flammable liquids]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (90.9%)
• Skin Corr. 1B (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.