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Atomfair Bis(2-methoxyethyl)aminosulphur trifluoride, 50% solution in THF Deoxo-Fluor C6H14F3NO2S

Description Bis(2-methoxyethyl)aminosulphur trifluoride, 50% solution in THF (CAS No. 202289-38-1) is a highly specialized fluorinating reagent widely used in organic synthesis. With the molecular formula C6H14F3NO2S and IUPAC name 2-methoxy-N-(2-methoxyethyl)-N-(trifluoro-lambda4-sulfanyl)ethanamine , this compound is supplied as a 50% solution in tetrahydrofuran (THF) for enhanced stability and handling. Known commercially as Deoxo-Fluor , it serves as a versatile alternative to hazardous reagents like DAST (Diethylaminosulfur trifluoride), offering superior selectivity and milder reaction conditions. Ideal for converting alcohols to fluorides, aldehydes/ketones to gem-difluorides, and carboxylic acids to acyl fluorides, this reagent is a staple in pharmaceutical, agrochemical, and materials science research. Packaged…

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Description

Description

Bis(2-methoxyethyl)aminosulphur trifluoride, 50% solution in THF (CAS No. 202289-38-1) is a highly specialized fluorinating reagent widely used in organic synthesis. With the molecular formula C6H14F3NO2S and IUPAC name 2-methoxy-N-(2-methoxyethyl)-N-(trifluoro-lambda4-sulfanyl)ethanamine, this compound is supplied as a 50% solution in tetrahydrofuran (THF) for enhanced stability and handling. Known commercially as Deoxo-Fluor, it serves as a versatile alternative to hazardous reagents like DAST (Diethylaminosulfur trifluoride), offering superior selectivity and milder reaction conditions. Ideal for converting alcohols to fluorides, aldehydes/ketones to gem-difluorides, and carboxylic acids to acyl fluorides, this reagent is a staple in pharmaceutical, agrochemical, and materials science research. Packaged under inert atmosphere to ensure purity, it is suitable for use in sensitive transformations requiring anhydrous conditions.

  • CAS No: 202289-38-1
  • Molecular Formula: C6H14F3NO2S
  • Molecular Weight: 221.24
  • Exact Mass: 221.06973435
  • Monoisotopic Mass: 221.06973435
  • IUPAC Name: 2-methoxy-N-(2-methoxyethyl)-N-(trifluoro-lambda4-sulfanyl)ethanamine
  • SMILES: COCCN(CCOC)S(F)(F)F
  • Synonyms: 202289-38-1, Bis(2-methoxyethyl)aminosulfur trifluoride, Deoxo-Fluor, Deoxy-fluor, DEOXO-FLUOR [MI]

Application

Bis(2-methoxyethyl)aminosulphur trifluoride (Deoxo-Fluor) is primarily employed as a fluorinating agent in organic synthesis, enabling efficient conversion of hydroxyl groups to fluorides with high stereochemical retention. It is particularly valuable for synthesizing fluorinated intermediates in drug discovery, such as protease inhibitors and PET imaging probes. The reagent also facilitates the transformation of carbonyl compounds to gem-difluoromethylene units, a critical step in the development of bioactive molecules. Its compatibility with THF as a solvent ensures ease of use in a wide range of reaction setups.

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