Description

Betamethasone 9,11-epoxide (CAS No. 981-34-0) is a high-purity synthetic steroid derivative, widely utilized in pharmaceutical research and development. This compound, with the molecular formula C₂₂H₂₈O₅, serves as a critical intermediate or impurity in the synthesis of glucocorticoids such as betamethasone and beclomethasone. Its well-defined epoxide structure at the 9,11-position makes it a valuable reference standard for analytical and quality control purposes in the pharmaceutical industry.

Available in various quantities, this product is rigorously tested for purity and stability, ensuring compliance with international standards (e.g., EP, USP). It is supplied as a white to off-white crystalline powder, soluble in organic solvents like methanol and DMSO, and should be stored under controlled conditions to maintain integrity. Ideal for researchers focusing on steroid chemistry, metabolic studies, or impurity profiling.

Properties

• CAS Number: 981-34-0
• Complexity: 814
• IUPAC Name: (1S,2S,10S,11S,13S,14R,15S,17S)-14-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyl-18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadeca-3,6-dien-5-one
• InChI: InChI=1S/C22H28O5/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)22(15)18(27-22)10-20(16,3)21(12,26)17(25)11-23/h6-7,9,12,15-16,18,23,26H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,18-,19-,20-,21-,22+/m0/s1
• InChI Key: GBDXNHBVYAMODG-DEGNENOVSA-N
• Exact Mass: 372.19367399
• Molecular Formula: C22H28O5
• Molecular Weight: 372.5
• SMILES: C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]35[C@@H](O5)C[C@@]2([C@]1(C(=O)CO)O)C)C
• Topological: 87.1
• Monoisotopic Mass: 372.19367399
• Synonyms: 981-34-0, Betamethasone 9,11-Epoxide, UNII-M9AY9BSI41, M9AY9BSI41, EINECS 213-563-4, BETAMETHASONE IMPURITY E [EP IMPURITY], Pregna-1,4-diene-3,20-dione, 9,11-epoxy-17,21-dihydroxy-16-methyl-, (9.beta.,11.beta.,16.beta.)-, BECLOMETHASONE DIPROPIONATE IMPURITY R [EP IMPURITY], 9,11beta-Epoxy-17,21-dihydroxy-16beta-methyl-9beta-pregna-1,4-diene-3,20-dione, 9,11.BETA.-EPOXY-17,21-DIHYDROXY-16.BETA.-METHYL-9.BETA.-PREGNA-1,4-DIENE-3,20-DIONE, 9.BETA.-PREGNA-1,4-DIENE-3,20-DIONE, 9,11.BETA.-EPOXY-17,21-DIHYDROXY-16.BETA.-METHYL-, BETAMETHASONE IMPURITY E (EP IMPURITY), BECLOMETHASONE DIPROPIONATE IMPURITY R (EP IMPURITY), Pregna-1,4-diene-3,20-dione, 9,11-epoxy-17,21-dihydroxy-16-methyl-, (9beta,11beta,16beta)-, 9BETA-PREGNA-1,4-DIENE-3,20-DIONE, 9,11BETA-EPOXY-17,21-DIHYDROXY-16BETA-METHYL-, 213-563-4, (4aS,4bS,5aS,6aS,7R,8S,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a,8-trimethyl-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one, (9beta,11beta,16beta)-9,11-Epoxy-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione, 16-beta Methyl Epoxide, (1S,2S,10S,11S,13S,14R,15S,17S)-14-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyl-18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadeca-3,6-dien-5-one, 9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione, 9b,11b-Epoxy-17,21-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione, MFCD09038712, 9beta,11beta-Epoxy-17,21-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione, DB11, SCHEMBL5262836, DTXSID601020538, AKOS017343721, CS-W006439, FB18569, AS-17685, DB-215100, NS00079643, C77355, Q27283711, (9|A,11|A,16|A)-9,11-Epoxy-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione, (9Beta,11beta,16beta)-17,21-dihydroxy-16-methyl-9,11-epoxypregna-1,4-diene-3,20-dione, 9 beta ,11 beta -Epoxy-17,21-dihydroxy-16 beta -methylpregna-1,4-diene-3,20-dione, 16alpha-Methyl epoxide(db-11); 17alpha,21-dihydroxy-9alpha,11alpha,epoxy-16alpha-methylpregn-1,4-diene-3,20-dione

Betamethasone 9,11-epoxide is primarily used as a reference standard in HPLC/LC-MS analyses to identify and quantify impurities in betamethasone and related corticosteroid formulations. It aids in method development and validation for compliance with pharmacopeial guidelines (EP/ICH). Researchers also employ it to study the metabolic pathways and stability of glucocorticoids, as well as in the synthesis of novel steroid derivatives for therapeutic exploration.

Safety and Hazards

GHS Hazard Statements

• Not Classified
• Reported as not meeting GHS hazard criteria by 8 of 8 companies. For more detailed information, please visit ECHA C&L website.

Hazard Classes and Categories

• Not Classified

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.