Description

Hydroxyethyl-beta-Cyclodextrin (HE-β-CD) is a chemically modified cyclodextrin derivative designed to enhance solubility, stability, and bioavailability of poorly water-soluble compounds. With the molecular formula C₅₆H₉₈O₄₂, this derivative features hydroxyethyl groups grafted onto the β-cyclodextrin backbone, improving its hydrophilic character while retaining its ability to form inclusion complexes. HE-β-CD is widely used in pharmaceutical formulations, biotechnology, and research applications due to its superior biocompatibility and low toxicity. This high-purity compound is rigorously tested for quality, ensuring optimal performance in drug delivery, solubility enhancement, and analytical applications. Available in bulk quantities for industrial and laboratory use, it is an essential tool for scientists and researchers working with hydrophobic molecules.

Properties

• CAS Number: 128446-32-2
• Complexity: 1800
• IUPAC Name: (1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35S,36R,37S,38R,39S,40R,41S,42R,43S,44R,45S,46R,47S,48R,49S)-37,39,41,43,45,47,49-heptakis(2-hydroxyethoxy)-5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,38,40,42,44,46,48-heptol
• InChI: InChI=1S/C56H98O42/c57-1-8-78-43-29(71)36-22(15-64)85-50(43)92-37-23(16-65)86-52(44(30(37)72)79-9-2-58)94-39-25(18-67)88-54(46(32(39)74)81-11-4-60)96-41-27(20-69)90-56(48(34(41)76)83-13-6-62)98-42-28(21-70)91-55(49(35(42)77)84-14-7-63)97-40-26(19-68)89-53(47(33(40)75)82-12-5-61)95-38-24(17-66)87-51(93-36)45(31(38)73)80-10-3-59/h22-77H,1-21H2/t22-,23-,24-,25-,26-,27-,28+,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43+,44+,45+,46+,47+,48+,49+,50-,51-,52-,53-,54-,55-,56-/m1/s1
• InChI Key: PCWPQSDFNIFUPO-KCVBUHIQSA-N
• Exact Mass: 1442.5532671
• Molecular Formula: C56H98O42
• Molecular Weight: 1443.3
• SMILES: C(CO[C@H]1[C@@H]([C@H]2[C@H](O[C@@H]1O[C@@H]3[C@H](O[C@@H]([C@H]([C@@H]3O)OCCO)O[C@@H]4[C@H](O[C@@H]([C@H]([C@@H]4O)OCCO)O[C@@H]5[C@H](O[C@@H]([C@H]([C@@H]5O)OCCO)O[C@@H]6[C@@H](O[C@@H]([C@H]([C@@H]6O)OCCO)O[C@@H]7[C@H](O[C@@H]([C@H]([C@@H]7O)OCCO)O[C@@H]8[C@H](O[C@H](O2)[C@H]([C@@H]8O)OCCO)CO)CO)CO)CO)CO)CO)CO)O)O
• Topological: 619
• Monoisotopic Mass: 1442.5532671
• Synonyms: 128446-32-2, .beta.-Cyclodextrin, 2-hydroxyethyl ethers, Hydroxyethyl beta-cyclodextrin, DA-64320

Hydroxyethyl-beta-Cyclodextrin is extensively utilized in pharmaceutical research to solubilize and stabilize hydrophobic drugs, enhancing their delivery and efficacy. It serves as a critical excipient in injectable formulations, improving drug solubility without compromising safety. Additionally, HE-β-CD is employed in analytical chemistry for sample preparation and chromatographic separation of complex mixtures. Its biocompatibility makes it suitable for use in cell culture media and diagnostic assays. Researchers also leverage its inclusion complexation properties for controlled-release drug systems and environmental remediation applications.

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