Description

3-Amino-4-hydroxy-N,N-dimethylbenzenesulfonamide (CAS No. 24962-75-2) is a high-purity sulfonamide derivative with the molecular formula C₈H₁₂N₂O₃S. This compound features a benzenesulfonamide core substituted with amino, hydroxy, and dimethylamino functional groups, making it a versatile intermediate for organic synthesis and pharmaceutical research. With a molecular weight of 216.26 g/mol, it is supplied as a fine powder or crystalline solid, ensuring consistent performance in laboratory applications. Ideal for researchers in medicinal chemistry, this compound is rigorously tested for purity (typically ≥95% by HPLC) and is packaged under inert conditions to ensure stability. Store in a cool, dry place away from light and moisture to maintain integrity.

Properties

• CAS Number: 24962-75-2
• Complexity: 283
• IUPAC Name: 3-amino-4-hydroxy-N,N-dimethyl-benzenesulfonamide
• InChI: InChI=1S/C8H12N2O3S/c1-10(2)14(12,13)6-3-4-8(11)7(9)5-6/h3-5,11H,9H2,1-2H3
• InChI Key: BLKRLPPJSAMUNN-UHFFFAOYSA-N
• Exact Mass: 216.05686342
• Molecular Formula: C8H12N2O3S
• Molecular Weight: 216.26
• SMILES: CN(C)S(=O)(=O)C1=CC(=C(C=C1)O)N
• Topological: 92
• Monoisotopic Mass: 216.05686342
• Synonyms: 24962-75-2, 3-Amino-4-hydroxy-N,N-dimethylbenzenesulfonamide, Benzenesulfonamide, 3-amino-4-hydroxy-N,N-dimethyl-, U3Z45B4CB7, EINECS 246-548-6, DTXSID2067038, DTXCID7037185, 246-548-6, 3-Amino-4-hydroxy-N,N-dimethylbenzenesulphonamide, N1,N1-DIMETHYL-3-AMINO-4-HYDROXYBENZENE-1-SULFONAMIDE, 3-amino-4-hydroxy-N,N-dimethylbenzene-1-sulfonamide, 3-Amino-4-Hydroxy-N,N-Dimethyl Benzenesulfonamide, MFCD00179913, UNII-U3Z45B4CB7, SCHEMBL6937115, BLKRLPPJSAMUNN-UHFFFAOYSA-N, RB3042, AKOS001453919, PS-4211, SB76987, DB-067287, CS-0061719, NS00027777, EN300-30586, Z303733784

Application

3-Amino-4-hydroxy-N,N-dimethylbenzenesulfonamide serves as a key intermediate in the synthesis of sulfonamide-based pharmaceuticals, particularly antimicrobial and diuretic agents. Its reactive amino and hydroxy groups enable facile derivatization for drug discovery and structure-activity relationship (SAR) studies. Researchers also utilize this compound in the development of dyes and pigments due to its aromatic sulfonamide backbone. Additionally, it finds use in analytical chemistry as a reference standard for chromatographic methods.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.