Description

Ethyl 2-(4-fluorophenyl)acetate (CAS No. 587-88-2) is a high-purity fluorinated aromatic ester with the molecular formula C₁₀H₁₁FO₂. This compound is a valuable synthetic intermediate in organic and pharmaceutical chemistry, characterized by its clear to pale-yellow liquid appearance and a mild, ester-like odor. With a molecular weight of 182.19 g/mol, it offers excellent solubility in common organic solvents such as ethanol, diethyl ether, and dichloromethane, while being sparingly soluble in water. Ideal for research and industrial applications, our product is rigorously tested to ensure ≥98% purity (GC) and is supplied in sealed, light-resistant containers to maintain stability. Suitable for use in Suzuki couplings, peptide modifications, and as a precursor for fluorinated fine chemicals.

Properties

• CAS Number: 587-88-2
• Complexity: 162
• IUPAC Name: ethyl 2-(4-fluorophenyl)acetate
• InChI: InChI=1S/C10H11FO2/c1-2-13-10(12)7-8-3-5-9(11)6-4-8/h3-6H,2,7H2,1H3
• InChI Key: VMWJHHAOVXQCLE-UHFFFAOYSA-N
• Exact Mass: 182.07430775
• Molecular Formula: C10H11FO2
• Molecular Weight: 182.19
• SMILES: CCOC(=O)CC1=CC=C(C=C1)F
• Topological: 26.3
• Monoisotopic Mass: 182.07430775
• Synonyms: 587-88-2, Ethyl 4-fluorophenylacetate, Benzeneacetic acid, 4-fluoro-, ethyl ester, Ethyl 4-fluorobenzeneacetate, Ethyl (p-fluorophenyl)acetate, Acetic acid, (p-fluorophenyl)-, ethyl ester, DTXSID90207400, DTXCID50129891, ethyl 2-(4-fluorophenyl)acetate, 4-FLUOROPHENYLACETIC ACID ETHYL ESTER, MFCD08235152, (4-Flurophenyl) acetic acid ethyl ester, (4-Flurophenyl)acetic acid ethyl ester, Ethyl2-(4-fluorophenyl)acetate, ethyl p-fluorophenylacetate, ethyl (4-fluorophenyl)acetate, SCHEMBL1626240, SCHEMBL16115071, VMWJHHAOVXQCLE-UHFFFAOYSA-N, AR2996, AKOS005259153, CS-W022645, GS-4515, (4-fluorophenyl)acetic acid ethyl ester, (4-fluorophenyl) acetic acid ethyl ester, SY021383, EN300-130231, Z53835949

Application

Ethyl 2-(4-fluorophenyl)acetate is widely employed as a key building block in the synthesis of fluorinated pharmaceuticals, agrochemicals, and liquid crystals. It serves as a versatile intermediate in cross-coupling reactions (e.g., Suzuki-Miyaura) to introduce fluorophenyl motifs into complex molecules. Researchers also utilize it in the development of prodrugs and fragrance compounds due to its hydrolytically labile ester group. Its fluorinated aromatic structure enhances bioavailability in drug discovery applications.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.