Description

2-(2-Fluorophenyl)acetic acid (CAS No. 451-82-1) is a high-purity fluorinated aromatic carboxylic acid with the molecular formula C₈H₇FO₂. This white to off-white crystalline powder is a valuable building block in organic synthesis and pharmaceutical research. With a molecular weight of 154.14 g/mol, this compound exhibits excellent chemical stability under standard laboratory conditions. Our product is rigorously tested to ensure ≥98% purity by HPLC, making it ideal for sensitive applications. The compound is supplied in amber glass bottles with argon packing to prevent degradation. Key applications include use as an intermediate in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) and other bioactive molecules. Store in a cool, dry place at 2-8°C for optimal shelf life.

Synonyms: 2-Fluorophenylacetic acid, o-Fluorophenylacetic acid, Benzeneacetic acid, 2-fluoro-, Acetic acid, (o-fluorophenyl)-, AI3-52626

Properties

• CAS Number: 451-82-1
• Complexity: 147
• IUPAC Name: 2-(2-fluorophenyl)acetic acid
• InChI: InChI=1S/C8H7FO2/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4H,5H2,(H,10,11)
• InChI Key: RPTRFSADOICSSK-UHFFFAOYSA-N
• Exact Mass: 154.04300762
• Molecular Formula: C8H7FO2
• Molecular Weight: 154.14
• SMILES: C1=CC=C(C(=C1)CC(=O)O)F
• Topological: 37.3
• Monoisotopic Mass: 154.04300762
• Synonyms: 2-Fluorophenylacetic acid, o-Fluorophenylacetic acid, Benzeneacetic acid, 2-fluoro-, Acetic acid, (o-fluorophenyl)-, AI3-52626, NSC 401, EINECS 207-196-9, DTXSID1060007, DTXCID6040379, 207-196-9, 451-82-1, 2-(2-fluorophenyl)acetic acid, MFCD00004315, 2-fluorobenzeneacetic acid, (2-fluorophenyl)acetic acid, X2W3C5ER3N, NSC-401, 2-Fluorophenyl acetic acid, (o-Fluorophenyl)acetic Acid; (2-Fluorophenyl)acetic Acid; (o-Fluorophenyl)acetic Acid; 2-(2-Fluorophenyl)ethanoic Acid; NSC 401; o-Fluorobenzeneacetic Acid, 2Fluorophenylacetic acid, UNII-X2W3C5ER3N, SCHEMBL8645, NSC401, SCHEMBL6969660, SCHEMBL22344588, SCHEMBL27617025, SCHEMBL28757846, 2-Fluorophenylacetic acid, 98%, BDBM16422, HY-Y0357, SBB057963, STL169023, AKOS000120439, AC-2853, BS-3849, CS-W020118, SY003125, DB-051274, F0205, NS00043466, ST50824461, EN300-21358, F2191-0060, Z104495526

Application

2-(2-Fluorophenyl)acetic acid serves as a key intermediate in pharmaceutical synthesis, particularly for fluorinated NSAIDs and analgesic compounds. Researchers utilize this compound in peptide coupling reactions to introduce fluorinated aromatic moieties. The fluorine substitution enhances metabolic stability in drug development applications. It’s also employed in material science for creating fluorinated liquid crystals and specialty polymers.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (18.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (16.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (18.8%)
• STOT SE 3 (16.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.