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Atomfair Benzene, 2-fluoro-4-methyl-1-nitro- 3-Fluoro-4-nitrotoluene C7H6FNO2

Description 2-Fluoro-4-methyl-1-nitrobenzene (CAS 128446-34-4) is a high-purity aromatic compound with the molecular formula C7H6FNO2. This fluorinated nitroaromatic derivative is an essential intermediate in organic synthesis, pharmaceutical research, and agrochemical development. Its unique structure, featuring a fluorine substituent ortho to a nitro group and a methyl group para to the nitro, enables selective reactivity in nucleophilic substitution and reduction reactions. Provided as a crystalline solid with ??98% purity (GC), it is ideal for Suzuki couplings, amination reactions, and heterocycle synthesis. Packaged under inert gas in amber glass vials to ensure stability. NMR, HPLC, and MS data available upon request.

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Description

Description

2-Fluoro-4-methyl-1-nitrobenzene (CAS 128446-34-4) is a high-purity aromatic compound with the molecular formula C7H6FNO2. This fluorinated nitroaromatic derivative is an essential intermediate in organic synthesis, pharmaceutical research, and agrochemical development. Its unique structure, featuring a fluorine substituent ortho to a nitro group and a methyl group para to the nitro, enables selective reactivity in nucleophilic substitution and reduction reactions. Provided as a crystalline solid with ??98% purity (GC), it is ideal for Suzuki couplings, amination reactions, and heterocycle synthesis. Packaged under inert gas in amber glass vials to ensure stability. NMR, HPLC, and MS data available upon request.

  • CAS No: 128446-34-4
  • Molecular Formula: C7H6FNO2
  • Molecular Weight: 155.13
  • Exact Mass: 155.03825660
  • Monoisotopic Mass: 155.03825660
  • IUPAC Name: 2-fluoro-4-methyl-1-nitrobenzene
  • SMILES: CC1=CC(=C(C=C1)[N+](=O)[O-])F
  • Synonyms: 3-Fluoro-4-nitrotoluene, 446-34-4, 2-Fluoro-4-methyl-1-nitrobenzene, Benzene, 2-fluoro-4-methyl-1-nitro-, gamma-Cyclodextrin, 2-hydroxypropyl ethers

Application

2-Fluoro-4-methyl-1-nitrobenzene serves as a key precursor in the synthesis of fluorinated anilines and benzimidazoles for pharmaceutical applications. Its electron-withdrawing nitro group facilitates palladium-catalyzed cross-coupling reactions to construct biaryl scaffolds. Researchers utilize this compound to develop PET radiotracers due to the fluorine-19 isotope’s utility in imaging. In material science, it acts as a monomer for fluorinated polyimides with enhanced thermal stability.

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