Description

2-Chloro-1,3-difluorobenzene (CAS No. 38361-37-4) is a high-purity halogenated aromatic compound with the molecular formula C₆H₃ClF₂. This colorless to pale-yellow liquid is a valuable intermediate in organic synthesis, particularly in the pharmaceutical and agrochemical industries. With a boiling point of approximately 135-137°C and a density of 1.35 g/cm³, it exhibits excellent solubility in common organic solvents while being immiscible with water. Our product is rigorously tested to ensure >98% purity (GC), making it ideal for research and industrial applications requiring precise chemical transformations. Proper handling with PPE is recommended due to its potential irritant properties.

Properties

• CAS Number: 38361-37-4
• Complexity: 87.1
• IUPAC Name: 2-chloro-1,3-difluoro-benzene
• InChI: InChI=1S/C6H3ClF2/c7-6-4(8)2-1-3-5(6)9/h1-3H
• InChI Key: OTZQYBFTOANOJO-UHFFFAOYSA-N
• Exact Mass: 147.9891341
• Molecular Formula: C6H3ClF2
• Molecular Weight: 148.54
• SMILES: C1=CC(=C(C(=C1)F)Cl)F
• Monoisotopic Mass: 147.9891341
• Synonyms: 2-Chloro-1,3-difluorobenzene, 38361-37-4, Benzene, 2-chloro-1,3-difluoro-, DTXSID90191719, DTXCID80114210, 672-495-7, 1-Chloro-2,6-difluorobenzene, MFCD00142604, 2,6-difluorochlorobenzene, chloro-2,6-difluorobenzene, Benzene,2-chloro-1,3-difluoro-, m-difluorochlorobenzene, SCHEMBL148941, SCHEMBL192809, SCHEMBL1042133, 2-Chloro-1,3-difluoro-benzene, SBB086607, AKOS006228199, CS-W018183, AS-30439, SY040901, DB-010044, C2211, EN300-123125, 1-Chloro-2,6-difluorobenzene;2,6-Difluorochlorobenzene

Application

2-Chloro-1,3-difluorobenzene serves as a key building block in the synthesis of advanced pharmaceutical compounds, particularly for introducing difluorophenyl motifs. It is widely utilized in cross-coupling reactions (e.g., Suzuki-Miyaura) to create biaryl structures in drug discovery. The compound also finds use in agrochemical production as a precursor for herbicides and pesticides. Its unique halogen pattern enables selective functionalization in materials science applications.

Safety and Hazards

GHS Hazard Statements

• H225 (33.3%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H226 (66.7%): Flammable liquid and vapor [Warning Flammable liquids]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (33.3%)
• Flam. Liq. 3 (66.7%)

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