Atomfair

Awaiting product image

Atomfair Benzene, 1-(chloromethyl)-2-fluoro- 2-Fluorobenzyl chloride C7H6ClF

Description 1-(Chloromethyl)-2-fluorobenzene (CAS No. 345-35-7) is a high-purity aromatic compound with the molecular formula C7H6ClF , widely utilized in organic synthesis and pharmaceutical research. This halogenated derivative of benzene features a reactive chloromethyl group adjacent to a fluorine substituent, making it a versatile intermediate for nucleophilic substitution reactions, cross-coupling, and functional group transformations. Available in >98% purity (GC), it is supplied in rigorously controlled conditions to ensure stability and consistency for sensitive applications. Ideal for synthesizing fluorinated analogs of bioactive molecules, ligands, or agrochemicals. Packaged in amber glass vials or sealed drums under inert gas to prevent degradation. MSDS and…

Category:
Brands:

Description

Description

1-(Chloromethyl)-2-fluorobenzene (CAS No. 345-35-7) is a high-purity aromatic compound with the molecular formula C7H6ClF, widely utilized in organic synthesis and pharmaceutical research. This halogenated derivative of benzene features a reactive chloromethyl group adjacent to a fluorine substituent, making it a versatile intermediate for nucleophilic substitution reactions, cross-coupling, and functional group transformations. Available in >98% purity (GC), it is supplied in rigorously controlled conditions to ensure stability and consistency for sensitive applications. Ideal for synthesizing fluorinated analogs of bioactive molecules, ligands, or agrochemicals. Packaged in amber glass vials or sealed drums under inert gas to prevent degradation. MSDS and analytical certificates (CoA, NMR, HPLC) provided.

  • CAS No: 345-35-7
  • Molecular Formula: C7H6ClF
  • Molecular Weight: 144.57
  • Exact Mass: 144.0142060
  • Monoisotopic Mass: 144.0142060
  • IUPAC Name: 1-(chloromethyl)-2-fluorobenzene
  • SMILES: C1=CC=C(C(=C1)CCl)F
  • Synonyms: 2-Fluorobenzyl chloride, 345-35-7, O-FLUOROBENZYL CHLORIDE, alpha-Chloro-o-fluorotoluene, Benzene, 1-(chloromethyl)-2-fluoro-

Application

1-(Chloromethyl)-2-fluorobenzene serves as a key building block in pharmaceutical intermediates, particularly for introducing fluorobenzyl motifs into drug candidates. It is employed in Suzuki-Miyaura couplings to create biaryl structures and in nucleophilic displacement reactions for heterocycle synthesis. Researchers also use it to develop fluorinated liquid crystals or agrochemicals due to its balanced reactivity and stability.

If you are interested or have any questions, please contact us at support@atomfair.com