Description

2-Chloro-5-(trifluoromethyl)aniline (CAS No. 121-50-6) is a high-purity aromatic amine derivative with the molecular formula C₇H₅ClF₃N. This compound features a trifluoromethyl group and a chloro substituent on the benzene ring, making it a versatile intermediate in organic synthesis and specialty chemical production. Its unique structure enhances reactivity in electrophilic substitution and coupling reactions, ideal for pharmaceutical, agrochemical, and material science applications. Available in crystalline form with ≥98% purity, it is rigorously tested via GC/HPLC to ensure consistency for research and industrial use. Store in a cool, dry place under inert conditions to maintain stability.

Properties

• CAS Number: 121-50-6
• Complexity: 159
• IUPAC Name: 2-chloro-5-(trifluoromethyl)aniline
• InChI: InChI=1S/C7H5ClF3N/c8-5-2-1-4(3-6(5)12)7(9,10)11/h1-3H,12H2
• InChI Key: VKTTYIXIDXWHKW-UHFFFAOYSA-N
• Exact Mass: 195.0062613
• Molecular Formula: C7H5ClF3N
• Molecular Weight: 195.57
• SMILES: C1=CC(=C(C=C1C(F)(F)F)N)Cl
• Topological: 26
• Monoisotopic Mass: 195.0062613
• Synonyms: 3-Amino-4-chlorobenzotrifluoride, 121-50-6, 2-Chloro-5-(trifluoromethyl)aniline, Benzenamine, 2-chloro-5-(trifluoromethyl)-, Fast Orange Salt RD, Orange Salt NRD, Daito Orange Salt RD, Diazo Fast Orange RD, Fast Orange Salt RDA, Fast Orange Salt RDN, Fast Orange RD Salt, Sanyo Fast Orange Salt RD, 4-Chloro-3-aminobenzotrifluoride, Azoene Fast Orange RD Salt, USAF MA-13, Hiltosal Fast Orange RD Salt, 6-Chloro-3-(trifluoromethyl)aniline, NSC 10318, C.I. 37050, CCRIS 2816, EINECS 204-475-7, BRN 0879910, AI3-26183, 3-Amino-4-chloro-alpha,alpha,alpha-trifluorotoluene, m-TOLUIDINE, 6-CHLORO-alpha,alpha,alpha-TRIFLUORO-, DTXSID1059525, 4-12-00-01852 (Beilstein Handbook Reference), DTXCID0033671, inchi=1/c7h5clf3n/c8-5-2-1-4(3-6(5)12)7(9,10)11/h1-3h,12h, 2-Chloro-5-trifluoromethylaniline, 6-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine, MFCD00007673, 7XBP8297PJ, NSC-10318, EN300-18346, m-Toluidine, 6-chloro-.alpha.,.alpha.,.alpha.-trifluoro-, 2-chloro-5-(trifluoromethyl)phenylamine, 2-chloro-5-(trifluoromethyl)benzenamine, 2-chloro-5-trifluoromethyl-phenylamine, WLN: ZR BG EXFFF, UNII-7XBP8297PJ, SCHEMBL330390, CHEMBL528932, SCHEMBL10451706, SCHEMBL12075928, 2-chloro-5-trifluoromethylanilin, BDBM626066, 2-chloro-5-trifluoromethyl aniline, 2-chloro-5-trifluoromethyl-aniline, NSC10318, SBB003593, STL281874, AKOS000119306, AC-3672, CS-W010614, PS-8282, ST082235, A0948, NS00004820, D77708, 6-Chloro-.alpha.,.alpha.-trifluoro-m-toluidine, 3-Amino-4-chloro-.alpha.,.alpha.-trifluorotoluene, 2-Chloro-5-(trifluoromethyl)aniline, >=98.0% (GC), Z57117627, 6-Chloro-.alpha.,.alpha.,.alpha.-trifluoro-m-toluidine, F5608-0076, 3-Amino-4-chloro-.alpha.,.alpha.,.alpha.-trifluorotoluene, 2-Chloro-5-trifluoromethylaniline;3-Amino-4-chlorobenzotrifluoride

Application

2-Chloro-5-(trifluoromethyl)aniline is widely used as a key intermediate in the synthesis of dyes, pigments, and agrochemicals. Its electron-withdrawing groups make it valuable in pharmaceutical research for developing bioactive molecules. The compound also serves as a building block in material science for creating advanced polymers and coatings with enhanced chemical resistance.

Safety and Hazards

GHS Hazard Statements

• H302 (94.5%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (94.5%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (61.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (60.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (94.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H411 (56.4%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P321, P330, P332+P317, P337+P317, P362+P364, P391, and P501

Hazard Classes and Categories

• Acute Tox. 4 (94.5%)
• Acute Tox. 4 (94.5%)
• Skin Irrit. 2 (61.8%)
• Eye Irrit. 2A (60.9%)
• Acute Tox. 4 (94.5%)
• Aquatic Chronic 2 (56.4%)

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