Description

2-Chloro-4-fluoroaniline (CAS No. 2106-02-7) is a high-purity aromatic amine compound with the molecular formula C₆H₅ClFN. This versatile intermediate is widely used in pharmaceutical, agrochemical, and specialty chemical synthesis due to its reactive amino and halogenated functional groups. Our product is supplied as a clear to pale yellow liquid with a purity of ≥99%, ensuring optimal performance in demanding applications. The compound’s unique structure, featuring both chloro and fluoro substituents on the aromatic ring, makes it particularly valuable for creating structurally diverse molecules through various coupling and substitution reactions. Strict quality control measures are implemented throughout production to guarantee batch-to-batch consistency, with comprehensive analytical data (including GC/MS, HPLC, and NMR) provided for research and industrial applications. Proper handling precautions should be observed as with all aromatic amines.

Properties

• CAS Number: 2106-02-7
• Complexity: 99.1
• IUPAC Name: 2-chloro-4-fluoro-aniline
• InChI: InChI=1S/C6H5ClFN/c7-5-3-4(8)1-2-6(5)9/h1-3H,9H2
• InChI Key: XRAKCYJTJGTSMM-UHFFFAOYSA-N
• Exact Mass: 145.0094550
• Molecular Formula: C6H5ClFN
• Molecular Weight: 145.56
• SMILES: C1=CC(=C(C=C1F)Cl)N
• Topological: 26
• Monoisotopic Mass: 145.0094550
• Synonyms: 2-Chloro-4-fluoroaniline, 2106-02-7, Benzenamine, 2-chloro-4-fluoro-, 2-chloro-4-fluorobenzenamine, DTXSID5062182, EINECS 218-282-0, DTXCID6036419, 218-282-0, MFCD00042530, 2-chloro-4-fluorophenylamine, 4-fluoro-2-chloroaniline, 2-chloro-4-fluoro-phenylamine, 2-chloro-4fluoroaniline, 2-chloro-4-fluroaniline, 2-chloro-4-fluoro aniline, SCHEMBL109905, SCHEMBL2318248, SCHEMBL7002860, (2-Chloro-4-fluorophenyl)amine, 2-chloranyl-4-fluoranyl-aniline, CHEMBL2323849, SCHEMBL27534355, 2-Chloro-4-fluoroaniline, 99%, (2-chloro-4-fluoro-phenyl)-amine, SBB004110, STL169018, AKOS000119578, CCG-302538, K77X364T56, PS-8958, AC-15876, DB-023638, CS-0017181, NS00046100, ST50823993, EN300-21348, A815110, F5608-0058, Z104495500, InChI=1/C6H5ClFN/c7-5-3-4(8)1-2-6(5)9/h1-3H,9H

2-Chloro-4-fluoroaniline serves as a key building block in pharmaceutical synthesis, particularly for active pharmaceutical ingredients (APIs) containing fluorinated aromatic systems. In agrochemical production, it’s utilized as an intermediate for advanced crop protection agents. The compound’s dual halogen functionality enables selective derivatization in medicinal chemistry applications, making it valuable for structure-activity relationship studies. Researchers also employ this chemical in material science for developing specialized dyes and functional polymers.

Safety and Hazards

GHS Hazard Statements

• H302 (97.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (89.6%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (97.9%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (89.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H373 (12.5%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (97.9%)
• Acute Tox. 4 (89.6%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (97.9%)
• STOT SE 3 (89.6%)
• STOT RE 2 (12.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.