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Atomfair Atabecestat JNJ-54861911 C18H14FN5OS

Description Atabecestat (CAS No. 1200493-78-2) is a high-purity small molecule inhibitor with the molecular formula C18H14FN5OS. This compound, also known by its IUPAC name N-[3-[(4S)-2-amino-4-methyl-1,3-thiazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide , is a selective beta-secretase (BACE1) inhibitor extensively studied for its potential therapeutic applications in neurodegenerative disorders. Atabecestat is supplied as a lyophilized powder with ??98% purity (HPLC) and is rigorously characterized by1H NMR, LC-MS, and elemental analysis to ensure batch-to-batch consistency. The product is packaged under inert gas in amber glass vials to ensure long-term stability and is suitable for in vitro and in vivo research applications. Store at -20??C under nitrogen atmosphere for…

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Description

Description

Atabecestat (CAS No. 1200493-78-2) is a high-purity small molecule inhibitor with the molecular formula C18H14FN5OS. This compound, also known by its IUPAC name N-[3-[(4S)-2-amino-4-methyl-1,3-thiazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide, is a selective beta-secretase (BACE1) inhibitor extensively studied for its potential therapeutic applications in neurodegenerative disorders. Atabecestat is supplied as a lyophilized powder with ??98% purity (HPLC) and is rigorously characterized by 1H NMR, LC-MS, and elemental analysis to ensure batch-to-batch consistency. The product is packaged under inert gas in amber glass vials to ensure long-term stability and is suitable for in vitro and in vivo research applications. Store at -20??C under nitrogen atmosphere for optimal stability.

  • CAS No: 1200493-78-2
  • Molecular Formula: C18H14FN5OS
  • Molecular Weight: 367.4
  • Exact Mass: 367.09030942
  • Monoisotopic Mass: 367.09030942
  • IUPAC Name: N-[3-[(4S)-2-amino-4-methyl-1,3-thiazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
  • SMILES: C[C@]1(C=CSC(=N1)N)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)C#N)F
  • Synonyms: Atabecestat, 1200493-78-2, JNJ-54861911, Atabecestat [INN], Atabecestat [USAN]

Application

Atabecestat is a potent and selective beta-secretase (BACE1) inhibitor developed for Alzheimer’s disease research. It demonstrates high blood-brain barrier permeability in preclinical models, making it valuable for studying amyloid-beta plaque reduction. The compound has been investigated in clinical trials for its potential to slow cognitive decline by inhibiting A?? peptide production.

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