Description

2,4-Difluoro-6-nitroaniline (CAS No. 364-30-7) is a high-purity fluorinated nitroaniline derivative with the molecular formula C₆H₄F₂N₂O₂. This compound is a valuable building block in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and specialty materials. Its unique structure, featuring two fluorine atoms and a nitro group on an aniline backbone, offers exceptional reactivity for nucleophilic aromatic substitution and other transformations. Available in >98% purity (HPLC), this product is rigorously tested for consistency and is supplied as a crystalline solid with excellent shelf stability. Ideal for research and industrial applications requiring precise fluorinated intermediates.

Properties

• CAS Number: 364-30-7
• Complexity: 185
• IUPAC Name: 2,4-difluoro-6-nitro-aniline
• InChI: InChI=1S/C6H4F2N2O2/c7-3-1-4(8)6(9)5(2-3)10(11)12/h1-2H,9H2
• InChI Key: WPEUQAOOZXFRKZ-UHFFFAOYSA-N
• Exact Mass: 174.02408370
• Molecular Formula: C6H4F2N2O2
• Molecular Weight: 174.10
• SMILES: C1=C(C=C(C(=C1[N+](=O)[O-])N)F)F
• Topological: 71.8
• Monoisotopic Mass: 174.02408370
• Synonyms: 2,4-Difluoro-6-nitroaniline, 364-30-7, ANILINE, 2,4-DIFLUORO-6-NITRO-, Benzenamine, 2,4-difluoro-6-nitro-, UM69Q7VNX7, NSC 81335, BRN 2722853, NSC-81335, 2,4-difluoro-6-nitrobenzenamine, DTXSID90189919, (2,4-DIFLUORO-6-NITROPHENYL)AMINE, DTXCID00112410, 609-244-8, MFCD00034058, EN300-102827, 2-Amino-3,5-difluoronitrobenzene, 4,6-difluoro-2-nitrophenylamine, NSC81335, UNII-UM69Q7VNX7, WLN: ZR BF DF FNW, NCIOpen2_000912, Aniline,4-difluoro-6-nitro-, SCHEMBL602423, WPEUQAOOZXFRKZ-UHFFFAOYSA-N, BDBM625961, BBL101665, SBB064415, STL555461, AKOS006227837, AC-9656, DS-14273, SY018633, DB-030789, CS-0146875, D4733

Application

2,4-Difluoro-6-nitroaniline serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, including potential kinase inhibitors and antimicrobial agents. Its electron-deficient aromatic ring facilitates the preparation of heterocyclic compounds via cyclization reactions. The compound is also utilized in agrochemical research for developing novel herbicides and pesticides with enhanced activity. Researchers leverage its fluorine substituents to modulate lipophilicity and bioavailability in drug discovery programs.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Acute Tox. 4 (50%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (50%)
• STOT SE 3 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.