Description

Alfadex (α-Cyclodextrin) is a highly purified cyclic oligosaccharide composed of six α-(1,4)-linked D-glucopyranose units, forming a toroidal structure with a hydrophobic interior and hydrophilic exterior. This unique molecular architecture enables Alfadex to act as a versatile host molecule for encapsulation, solubilization, and stabilization of hydrophobic guest compounds in aqueous solutions. With a molecular formula of C₃₆H₆₀O₃₀ and CAS number 10016-20-3, our pharmaceutical-grade Alfadex meets stringent quality standards (≥98% purity by HPLC) for research and industrial applications. It is produced under cGMP conditions, ensuring batch-to-batch consistency for critical applications in drug formulation, food science, and chemical analysis. The product is supplied as a white crystalline powder with excellent water solubility (14.5 g/100 mL at 25°C) and undergoes rigorous analytical testing including residual solvent analysis, heavy metal screening, and microbiological quality control.

Properties

• CAS Number: 10016-20-3
• Complexity: 1250
• IUPAC Name: (1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41R,42R)-5,10,15,20,25,30-hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxaheptacyclo[26.2.2.23,6.28,11.213,16.218,21.223,26]dotetracontane-31,32,33,34,35,36,37,38,39,40,41,42-dodecol
• InChI: InChI=1S/C36H60O30/c37-1-7-25-13(43)19(49)31(55-7)62-26-8(2-38)57-33(21(51)15(26)45)64-28-10(4-40)59-35(23(53)17(28)47)66-30-12(6-42)60-36(24(54)18(30)48)65-29-11(5-41)58-34(22(52)16(29)46)63-27-9(3-39)56-32(61-25)20(50)14(27)44/h7-54H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-/m1/s1
• InChI Key: HFHDHCJBZVLPGP-RWMJIURBSA-N
• Exact Mass: 972.31694049
• Molecular Formula: C36H60O30
• Molecular Weight: 972.8
• SMILES: C([C@@H]1[C@@H]2[C@@H]([C@H]([C@H](O1)O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]4[C@H](O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]5[C@H](O[C@@H]([C@@H]([C@H]5O)O)O[C@@H]6[C@H](O[C@@H]([C@@H]([C@H]6O)O)O[C@@H]7[C@H](O[C@H](O2)[C@@H]([C@H]7O)O)CO)CO)CO)CO)CO)O)O)O
• Topological: 475
• Monoisotopic Mass: 972.31694049
• Physical Description: Hexagonal plates or blade-shaped needles.
• Melting Point: 532 °F
• Synonyms: alpha-CYCLODEXTRIN, 10016-20-3, Alfadex, Cyclohexapentylose, a-cyclodextrin, Cyclomaltohexaose, alpha-Dextrin, Cyclohexaamylose, Cyclomaltohexose, alpha-Schardinger dextrin, .alpha.-Cyclodextrin, alpha cyclodextrin, alpha-Cycloamylose, Alfadexum, Alfadex [INN], Dextrin, alpha-cyclo, Oristar acd, Ringdex-a, Alfadexum [INN-Latin], Cavamax w6, Cyclohexaamylose carbonate, Cavamax w 6 food, Celdex a 100, Ins no.457, Z1LH97KTRM, Alfadex [INN:BAN:NF], Dexy pearl .alpha.-100, EINECS 233-007-4, Ins-457, Alpha-Cyclodextrin (Cyclohexa-Amylose), NSC 269470, DTXSID7030698, CHEBI:40585, ALFADEX [II], ALFADEX [MART.], ALFADEX [WHO-DD], NSC-269470, ALFADEX [EP MONOGRAPH], ALPHA-CYCLODEXTRIN [FCC], DTXCID5010698, E-457, EC 233-007-4, .ALPHA.-CYCLODEXTRIN [MI], ALPHA CYCLODEXTRIN [USP-RS], Alfadexum (INN-Latin), ALFADEX (II), ALFADEX (MART.), (1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41R,42R)-5,10,15,20,25,30-hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxaheptacyclo[26.2.2.23,6.28,11.213,16.218,21.223,26]dotetracontane-31,32,33,34,35,36,37,38,39,40,41,42-dodecol, ALFADEX (EP MONOGRAPH), ALPHA CYCLODEXTRIN (USP-RS), alpha-CD, (1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41R,42R)-5,10,15,20,25,30-hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxaheptacyclo(26.2.2.23,6.28,11.213,16.218,21.223,26)dotetracontane-31,32,33,34,35,36,37,38,39,40,41,42-dodecol, (1S,3S,5R,6S,8S,10S,11S,13S,15S,16S,18S,20S,21S,23S,25S,26S,28S,30S,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41R,42R)-5,10,15,20,25,30-hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxaheptacyclo(26.2.2.23,6.28,11.213,16.218,21.223,26)dotetracontane-31,32,33,34,35,36,37,38,39,40,41,42-dodecol, (1S,3S,5R,6S,8S,10S,11S,13S,15S,16S,18S,20S,21S,23S,25S,26S,28S,30S,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41R,42R)-5,10,15,20,25,30-hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxaheptacyclo[26.2.2.23,6.28,11.213,16.218,21.223,26]dotetracontane-31,32,33,34,35,36,37,38,39,40,41,42-dodecol, 2,4,7,9,12,14,17,19,22,24,27,29-DODECAOXAHEPTACYCLO(26.2.2.23,6.28,11.213,16.218,21.223,26)DOTETRACONTANE, ALPHA-CYCLODEXTRIN DERIV., 2,4,7,9,12,14,17,19,22,24,27,29-DODECAOXAHEPTACYCLO[26.2.2.23,6.28,11.213,16.218,21.223,26]DOTETRACONTANE, ALPHA-CYCLODEXTRIN DERIV., STEREOISOMER OF 5,10,15,20,25,30-HEXAKIS(HYDROXYMETHYL)-2,4,7,9,12,14,17,19,22,24,27,29-DODECAOXAHEPTACYCLO(26.2.2.23,6.28,11.213,16.218,21.223,26)DOTETRACONTANE-31,32,33,34,35,36,37,38,39,40,41,42-DODECOL, STEREOISOMER OF 5,10,15,20,25,30-HEXAKIS(HYDROXYMETHYL)-2,4,7,9,12,14,17,19,22,24,27,29-DODECAOXAHEPTACYCLO[26.2.2.23,6.28,11.213,16.218,21.223,26]DOTETRACONTANE-31,32,33,34,35,36,37,38,39,40,41,42-DODECOL, CYCLOHEXADEXTRIN, RINGDEX A, DEXY PEARL ALPHA-100, 233-007-4, NCGC00090767-02, MFCD00078207, CAS-10016-20-3, UNII-Z1LH97KTRM, 2zym, 3zst, 4fem, Alfadex; Cyclohexakis-(1?4)-(a-D-glucopyranosyl) (cyclomaltohexaose); Cyclohexakis-(1?4)-(a-D-glucopyranosyl) a-cyclodextrin, alpha -Cyclodextrin, Alfadex (INN/NF), 3ck7, BDBM4, aCD; ?CD, SCHEMBL24981, alpha-Cyclodextrin, >=98%, MLS001074882, CHEMBL1230813, hexakis(hydroxymethyl)[?]dodecol, HMS2232K21, HY-B1513, Tox21_111015, Tox21_201252, Tox21_300302, MSK158667, AKOS015900446, DB01909, OC06644, NCGC00090767-01, NCGC00090767-03, NCGC00090767-04, NCGC00253988-01, NCGC00258804-01, AS-10392, BP-31069, SMR000568406, CS-0013302, NS00007829, alpha-Cyclodextrin, purum, >=98.0% (HPLC), D08846, I11498, Q27104460, Alfadex, European Pharmacopoeia (EP) Reference Standard, Alpha Cyclodextrin, United States Pharmacopeia (USP) Reference Standard, alpha-Cyclodextrin, powder, BioReagent, suitable for cell culture, >=98%, alpha-Cyclodextrin, produced by Wacker Chemie AG, Burghausen, Germany, >=99.0% (HPLC), (1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41R,42R)-5,10,15,20,25,30-hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxaheptacyclo[26.2.2.2^{3,6}.2^{8,11}.2^{13,16}.2^{18,21}.2^{23,26}]dotetracontane-31,32,33,34,35,36,37,38,39,40,41,42-dodecol, alpha-Cyclodextrin, FG, produced by Wacker Chemie AG, Burghausen, Germany, Food, >=98% (on dry substance), alpha-Cyclodextrin, Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, 98.0-101.0% cyclodextrin basis (HPLC)

Alfadex serves as a molecular carrier in drug delivery systems to enhance solubility and bioavailability of poorly water-soluble pharmaceuticals. In analytical chemistry, it functions as a chiral selector for enantiomeric separation in capillary electrophoresis and HPLC. The compound finds extensive use in food technology as a flavor stabilizer and in cosmetic formulations for fragrance encapsulation. Researchers utilize its host-guest complexation properties for enzyme mimetics and supramolecular chemistry studies.

Safety and Hazards

GHS Hazard Statements

• Not Classified
• Reported as not meeting GHS hazard criteria by 73 of 77 companies (only 5.2% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

Hazard Classes and Categories

• Not Classified

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