Description

Description

2-Chloro-2,2-difluoroacetyl fluoride (CAS No. 354-27-8) is a highly specialized fluorinated organic compound with the molecular formula C₂ClF₃O. This colorless to pale yellow liquid is characterized by its reactive acyl fluoride functional group, making it a valuable intermediate in advanced chemical synthesis. With a molecular weight of 132.48 g/mol, it exhibits high purity (>98%) and is packaged under inert gas to ensure stability. Its unique combination of chloro and difluoro substituents on the acetyl moiety enables precise control in nucleophilic substitution and fluorination reactions. This compound is particularly useful in pharmaceutical and agrochemical research where selective fluorination is required. Proper handling requires anhydrous conditions and personal protective equipment due to its moisture sensitivity and potential to release HF upon hydrolysis. Available in research quantities (1g to 5kg) with optional custom purity and packaging.

Application

This compound serves as a key building block for introducing the -COF group in fluorinated molecules, particularly in the synthesis of active pharmaceutical ingredients (APIs) requiring selective fluorination. It’s employed in the development of novel anesthetic agents and refrigerant precursors due to its stable yet reactive fluorinated structure. Researchers utilize it as a versatile intermediate in organofluorine chemistry to create compounds with enhanced metabolic stability and bioavailability.

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