Description

Acetic acid, trifluoro-, (2Z)-piperazinylidenehydrazide (CAS No. 763105-70-0) is a high-purity fluorinated hydrazide derivative with the molecular formula C₆H₉F₃N₄O. This compound, also known by its IUPAC name 2,2,2-trifluoro-N’-(1,2,3,6-tetrahydropyrazin-5-yl)acetohydrazide, is a specialized reagent designed for advanced synthetic and medicinal chemistry applications. Its unique structure, featuring a trifluoroacetyl group and a piperazinylidenehydrazide moiety, makes it a valuable intermediate in the development of fluorinated pharmaceuticals, agrochemicals, and ligand synthesis.

Our product is rigorously tested for purity (>95% by HPLC) and stability, ensuring reliable performance in sensitive reactions. It is supplied as a crystalline solid under inert packaging to prevent degradation. Ideal for researchers exploring heterocyclic chemistry, fluorine-based drug design, or coordination complexes, this compound offers exceptional reactivity in nucleophilic substitution and cyclization reactions.

Properties

• CAS Number: 763105-70-0
• Complexity: 250
• IUPAC Name: 2,2,2-trifluoro-N’-(1,2,3,6-tetrahydropyrazin-5-yl)acetohydrazide
• InChI: InChI=1S/C6H9F3N4O/c7-6(8,9)5(14)13-12-4-3-10-1-2-11-4/h10H,1-3H2,(H,11,12)(H,13,14)
• InChI Key: RKIDLJBEMIARHI-UHFFFAOYSA-N
• Exact Mass: 210.07284541
• Molecular Formula: C6H9F3N4O
• Molecular Weight: 210.16
• SMILES: C1CN=C(CN1)NNC(=O)C(F)(F)F
• Topological: 65.5
• Monoisotopic Mass: 210.07284541
• Synonyms: Acetic acid, trifluoro-, (2Z)-piperazinylidenehydrazide, 616-320-4, 849832-73-1, 763105-70-0, (Z)-2,2,2-trifluoro-N’-(piperazin-2-ylidene)acetohydrazide, N-[(2Z)-Piperazin-2-ylidene]-2,2,2-trifluoroacetohydrazide, 2,2,2-trifluoro-N’-[(2Z)-piperazin-2-ylidene]acetohydrazide, N’-[(2Z)-Piperazin-2-ylidene]trifluoroacetohydrazide, 2,2,2-trifluoro-N’-(1,2,3,6-tetrahydropyrazin-5-yl)acetohydrazide, 2,2,2-Trifluoro-N’-(piperazin-2-ylidene)acetohydrazide, 764667-63-2, 2,2,2-trifluoro-N’-(3,4,5,6-tetrahydropyrazin-2-yl)acetohydrazide, 2,2,2-Trifluoro-N-[(Z)-piperazin-2-ylideneamino]acetamide-T11014, acetic acid, 2,2,2-trifluoro-, (2z)-2-(2-piperazinylidene)hydrazide, 2,2,2-Trifluoro-N’-((2Z)-piperazin-2-ylidene)acetohydrazide, Acetic acid, 2,2,2-trifluoro-, (2Z)-2-(2-piperazinylidene)hydrazide; Acetic acid, trifluoro-, (2Z)-2-(2-piperazinylidene)hydrazide (9CI); Acetic acid, trifluoro-, (2Z)-piperazinylidenehydrazide; N-[(2Z)-Piperazin-2-ylidene]-2,2,2-trifluoroacetohydrazide; N’-[(2Z)-Piperazin-2-ylidene]trifluoroacetohydrazide, MFCD09833209, H9BUL69YLE, EC 616-320-4, SCHEMBL2853721, SCHEMBL2853724, SCHEMBL18774234, DTXSID50434513, 2,2,2-Trifluoro-N-[(Z)-piperazin-2-ylideneamino]acetamide, Acetic acid, 2,2,2-triflu…, CS-M0691, AKOS015966840, AC-8856, FP95705, AS-34164, SY241112, NS00008087, N’-((Z)-piperazin-2-ylidene)-trifluoroacetohydrazide, 2,2,2-Trifluoroacetic acid (2Z)-2-(2-piperazinylidene)hydrazide, 2,2,2-Trifluoro-N inverted exclamation mark -(piperazin-2-ylidene)acetohydrazide

Application

This trifluoroacetyl hydrazide derivative serves as a key building block in the synthesis of fluorinated heterocycles, particularly in the development of bioactive molecules targeting CNS disorders. Its reactive hydrazide group enables efficient construction of pyrazole and triazole scaffolds in medicinal chemistry. Researchers also utilize it as a precursor for metal-chelating ligands in catalytic systems, leveraging the electron-withdrawing trifluoromethyl group to modulate reactivity.

Safety and Hazards

GHS Hazard Statements

• Not Classified
• Reported as not meeting GHS hazard criteria by 1 of 1 companies. For more detailed information, please visit ECHA C&L website.

Hazard Classes and Categories

• Not Classified

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