Description

8-Bromoguanosine (CAS: 4016-63-1) is a brominated derivative of guanosine, a nucleoside critical for RNA synthesis and cellular signaling. This high-purity compound, with the molecular formula C₁₀H₁₂BrN₅O₅, is widely used in biochemical research, particularly in studies involving nucleic acid structure, function, and modification. Its bromine substitution at the 8-position enhances its utility as a probe for investigating RNA-protein interactions, polymerase mechanisms, and nucleoside analog applications. Suitable for HPLC, NMR, and mass spectrometry analysis, our 8-Bromoguanosine is rigorously tested for purity (>98%) and stability, ensuring reliable performance in sensitive experiments. Available in lyophilized powder form, it is ideal for molecular biology, enzymology, and pharmaceutical research.

Properties

• CAS Number: 4016-63-1
• Complexity: 479
• IUPAC Name: 2-amino-8-bromo-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-purin-6-one
• InChI: InChI=1S/C10H12BrN5O5/c11-9-13-3-6(14-10(12)15-7(3)20)16(9)8-5(19)4(18)2(1-17)21-8/h2,4-5,8,17-19H,1H2,(H3,12,14,15,20)/t2-,4-,5-,8-/m1/s1
• InChI Key: ASUCSHXLTWZYBA-UMMCILCDSA-N
• Exact Mass: 361.00218
• Molecular Formula: C10H12BrN5O5
• Molecular Weight: 362.14
• SMILES: C([C@@H]1[C@H]([C@H]([C@@H](O1)N2C3=C(C(=O)NC(=N3)N)N=C2Br)O)O)O
• Topological: 155
• Monoisotopic Mass: 361.00218
• Synonyms: 8-Bromoguanosine, 4016-63-1, EINECS 223-677-6, NSC 79211, NSC 174257, 223-677-6, Guanosine, 8-bromo-, 8-Bromo-guanosine, 2-amino-8-bromo-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one, MFCD00037985, 8 BrGuo, 8-bromo guanosine, 2-amino-8-bromo-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one, 2-AMINO-8-BROMO-9-[(2R,3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-1H-PURIN-6-ONE, C10H12BrN5O5, 8-bro-moguanosine, SCHEMBL56018, CHEMBL3246762, CHEBI:183722, HG1301, NSC816043, AKOS015955615, AKOS040768044, NB06311, NSC-816043, 2-amino-8-bromo-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one, AC-32296, AS-19159, PD017498, DB-318393, NS00049217, EN300-30595405, Q27458387, 2-Amino-8-bromo-6-hydroxypurine riboside;8-Bromo-D-guanosine, (2R,3R,4S,5R)-2-(2-amino-8-bromo-6-hydroxy-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol, 2-amino-8-bromo-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one, 2-amino-8-bromo-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one, 2-Amino-8-bromo-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one, 2-amino-8-bromo-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one, 2-amino-8-bromo-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-purin-6-one, BG2

8-Bromoguanosine is primarily used as a modified nucleoside in RNA research, enabling the study of nucleic acid structure and enzyme interactions. It serves as a valuable tool in polymerase assays and mechanistic studies of RNA-processing enzymes. Researchers also employ it to investigate nucleoside analogs for antiviral or anticancer drug development. Additionally, its fluorescence-quenching properties make it useful in spectroscopic analyses of RNA dynamics.

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