Description

7-Amino-1,8-naphthyridin-2(1H)-one sulfate (CAS No. 632620-24-7) is a high-purity organic compound with the molecular formula C₈H₉N₃O₅S. This specialized chemical is a sulfate salt derivative of 7-amino-1,8-naphthyridin-2-one, offering enhanced solubility and stability for research applications. The compound features a naphthyridine core, a privileged scaffold in medicinal chemistry, with an amino group at the 7-position and a keto group at the 2-position. Our product is synthesized under strict quality control measures, ensuring >95% purity by HPLC analysis. The material is provided as a crystalline solid with comprehensive analytical data including ¹H NMR, ¹³C NMR, and mass spectrometry characterization. Ideal for pharmaceutical research, this building block is particularly valuable for developing kinase inhibitors, antimicrobial agents, and other biologically active compounds targeting heterocyclic recognition motifs.

Properties

• CAS Number: 632620-24-7
• Complexity: 308
• IUPAC Name: 7-amino-1H-1,8-naphthyridin-2-one;sulfuric acid
• InChI: InChI=1S/C8H7N3O.H2O4S/c9-6-3-1-5-2-4-7(12)11-8(5)10-6;1-5(2,3)4/h1-4H,(H3,9,10,11,12);(H2,1,2,3,4)
• InChI Key: JEBQCMSNZMRCQV-UHFFFAOYSA-N
• Exact Mass: 259.02629157
• Molecular Formula: C8H9N3O5S
• Molecular Weight: 259.24
• SMILES: C1=CC(=NC2=C1C=CC(=O)N2)N.OS(=O)(=O)O
• Topological: 151
• Monoisotopic Mass: 259.02629157
• Synonyms: 632620-24-7, 7-Amino-1H-[1,8]naphthyridin-2-one sulfate, 7-AMINO-1,8-NAPHTHYRIDIN-2(1H)-ONE SULFATE, 7-amino-1H-1,8-naphthyridin-2-one;sulfuric acid, SCHEMBL5076874, SCHEMBL5202954, DTXSID50622256, JEBQCMSNZMRCQV-UHFFFAOYSA-N, DB-350699, 2-amino-7-hydroxy-1,8-naphthyridine sulfuric acid salt, Sulfuric acid–7-amino-1,8-naphthyridin-2(1H)-one (1/1)

Application

7-Amino-1,8-naphthyridin-2(1H)-one sulfate serves as a key intermediate in medicinal chemistry for the synthesis of potential kinase inhibitors. The naphthyridine core structure makes it valuable for developing antibacterial and antiviral compounds targeting DNA gyrase and topoisomerase enzymes. Researchers utilize this building block in structure-activity relationship studies due to its hydrogen bonding capability and planar aromatic system. The sulfate salt form offers improved aqueous solubility for biological testing compared to the free base.

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