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Atomfair 6,6-Difluoro-2-azaspiro[3.3]heptane 2,2,2-trifluoroacetate C8H10F5NO2 CAS 1427367-47-2

6,6-Difluoro-2-azaspiro[3.3]heptane 2,2,2-trifluoroacetate (CAS No. 1427367-47-2) is a high-purity fluorinated spirocyclic compound with the molecular formula C8H10F5NO2. This specialized chemical is designed for advanced research applications, particularly in medicinal chemistry, agrochemical development, and materials science. The compound features a unique spiro[3.3]heptane core with strategic fluorine substitutions, enhancing its reactivity and metabolic stability for drug discovery applications. It is supplied as a trifluoroacetate salt for improved solubility and handling. Rigorous QC ensures ≥95% purity (HPLC), with batch-specific certificates of analysis provided. Store desiccated at -20°C under inert atmosphere to maintain stability. Suitable for Suzuki couplings, peptide modifications, and as a building block…

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Description

6,6-Difluoro-2-azaspiro[3.3]heptane 2,2,2-trifluoroacetate (CAS No. 1427367-47-2) is a high-purity fluorinated spirocyclic compound with the molecular formula C8H10F5NO2. This specialized chemical is designed for advanced research applications, particularly in medicinal chemistry, agrochemical development, and materials science. The compound features a unique spiro[3.3]heptane core with strategic fluorine substitutions, enhancing its reactivity and metabolic stability for drug discovery applications. It is supplied as a trifluoroacetate salt for improved solubility and handling. Rigorous QC ensures ≥95% purity (HPLC), with batch-specific certificates of analysis provided. Store desiccated at -20°C under inert atmosphere to maintain stability. Suitable for Suzuki couplings, peptide modifications, and as a building block for bioactive molecule synthesis.

Properties

  • CAS Number: 1427367-47-2
  • Complexity: 213
  • IUPAC Name: 6,6-difluoro-2-azaspiro[3.3]heptane;2,2,2-trifluoroacetic acid
  • InChI: InChI=1S/C6H9F2N.C2HF3O2/c7-6(8)1-5(2-6)3-9-4-5;3-2(4,5)1(6)7/h9H,1-4H2;(H,6,7)
  • InChI Key: VADHXGWRJYIASW-UHFFFAOYSA-N
  • Exact Mass: 247.06316937
  • Molecular Formula: C8H10F5NO2
  • Molecular Weight: 247.16
  • SMILES: C1C2(CC1(F)F)CNC2.C(=O)(C(F)(F)F)O
  • Topological: 49.3
  • Monoisotopic Mass: 247.06316937
  • Synonyms: 1427367-47-2, 6,6-Difluoro-2-azaspiro[3.3]heptane 2,2,2-trifluoroacetate, 6,6-Difluoro-2-aza-spiro[3.3]heptane trifluoroacetate, 6,6-difluoro-2-azaspiro[3.3]heptane trifluoroacetate, MFCD20922769, 6,6-difluoro-2-azaspiro[3.3]heptane;2,2,2-trifluoroacetic acid, 2,2-Difluoro-6-azaspiro[3.3]heptane; 2,2,2-trifluoroacetic acid, SCHEMBL20241328, VADHXGWRJYIASW-UHFFFAOYSA-N, AC9815, AKOS025289847, PB23058, SB19895, AS-34287, SY102705, 6,6-Difluoro-2-azaspiro[3.3]heptane TFA, CS-0050371, 6,6-Difluoro-2-aza-spiro-[3.3]heptane trifluoroacetate, 6,6-Difluoro-2-azaspiro[3.3]heptane2,2,2-trifluoroacetate

This fluorinated spirocyclic scaffold is widely utilized in pharmaceutical R&D as a conformationally constrained building block for kinase inhibitors and GPCR-targeted therapeutics. Its lipophilic character enhances blood-brain barrier penetration, making it valuable for CNS drug discovery. The compound also serves as a key intermediate in the synthesis of fluorinated analogs for metabolic stability studies. Researchers employ it in fragment-based drug design due to its three-dimensional architecture.

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Disclaimer

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