Atomfair 6-(Trifluoromethyl)pyridine-2-carboxylic acid C7H4F3NO2 CAS 131747-42-7

Description

6-(Trifluoromethyl)pyridine-2-carboxylic acid (CAS No. 131747-42-7) is a high-purity fluorinated pyridine derivative with the molecular formula C₇H₄F₃NO₂. This compound features a trifluoromethyl group at the 6-position and a carboxylic acid moiety at the 2-position of the pyridine ring, making it a versatile building block for pharmaceutical, agrochemical, and material science applications. Its unique electronic and steric properties enhance reactivity in cross-coupling, nucleophilic substitution, and metal-catalyzed reactions. Available in ≥98% purity (HPLC), it is supplied as a white to off-white crystalline powder with excellent batch-to-batch consistency. Store under inert conditions at 2-8°C to ensure long-term stability. Suitable for research, process development, and scale-up synthesis.

Properties

• CAS Number: 131747-42-7
• Complexity: 204
• IUPAC Name: 6-(trifluoromethyl)pyridine-2-carboxylic acid
• InChI: InChI=1S/C7H4F3NO2/c8-7(9,10)5-3-1-2-4(11-5)6(12)13/h1-3H,(H,12,13)
• InChI Key: OKBHXGBLXDNJJD-UHFFFAOYSA-N
• Exact Mass: 191.01941286
• Molecular Formula: C7H4F3NO2
• Molecular Weight: 191.11
• SMILES: C1=CC(=NC(=C1)C(F)(F)F)C(=O)O
• Topological: 50.2
• Monoisotopic Mass: 191.01941286
• Synonyms: 131747-42-7, 6-(Trifluoromethyl)pyridine-2-carboxylic acid, 6-trifluoromethyl-2-pyridinecarboxylic acid, DTXSID30563698, DTXCID40514474, 688-544-0, 6-(trifluoromethyl)picolinic acid, 2-Trifluoromethyl-6-pyridinecarboxylic acid, 2-Pyridinecarboxylic acid, 6-(trifluoromethyl)-, 6-(TRIFLUOROMETHYL)-2-PYRIDINECARBOXYLIC ACID, 6-Trifluoromethylpyridine-2-carboxylic acid, MFCD02180819, 6-TRIFLUOROMETHYL-PYRIDINE-2-CARBOXYLIC ACID, 155377-07-4, SCHEMBL496206, BCP28159, BBL102545, SBB053023, STL556348, 6-(trifluoromethyl)picolinic acid, 2-carboxy-6-(trifluoromethyl)pyridine, AKOS005063820, AB11449, CS-W007960, FS-2389, AC-23039, SY023407, DB-011844, T3270, EN300-96296, 6-(Trifluoromethyl)pyridine-2-carboxylic acid, 97%, Z1201621669

Application

6-(Trifluoromethyl)pyridine-2-carboxylic acid is widely used as a key intermediate in the synthesis of bioactive molecules, particularly in the development of pharmaceuticals and agrochemicals. Its trifluoromethyl group enhances metabolic stability and lipophilicity, making it valuable in drug discovery for CNS and antiviral agents. The compound also serves as a ligand precursor in catalysis and a monomer for specialty polymers with tailored electronic properties.

Safety and Hazards

GHS Hazard Statements

• H302 (90.5%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (90.5%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.