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Atomfair 6-(Trifluoromethyl)nicotinic acid C7H4F3NO2

Description 6-(Trifluoromethyl)nicotinic acid (CAS No. 231291-22-8) is a high-purity fluorinated pyridine derivative with the molecular formula C7H4F3NO2and IUPAC name 6-(trifluoromethyl)pyridine-3-carboxylic acid . This compound is a versatile building block in pharmaceutical and agrochemical synthesis, featuring a reactive carboxylic acid group and a stable trifluoromethyl substituent at the 6-position of the pyridine ring. Its unique electronic properties enhance bioavailability and metabolic stability in drug candidates. Available in >98% purity (HPLC), it is supplied as a white to off-white crystalline powder with strict QC protocols including NMR, LC-MS, and elemental analysis. Store under inert conditions at 2-8??C to maintain stability. Ideal for…

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Description

Description

6-(Trifluoromethyl)nicotinic acid (CAS No. 231291-22-8) is a high-purity fluorinated pyridine derivative with the molecular formula C7H4F3NO2 and IUPAC name 6-(trifluoromethyl)pyridine-3-carboxylic acid. This compound is a versatile building block in pharmaceutical and agrochemical synthesis, featuring a reactive carboxylic acid group and a stable trifluoromethyl substituent at the 6-position of the pyridine ring. Its unique electronic properties enhance bioavailability and metabolic stability in drug candidates. Available in >98% purity (HPLC), it is supplied as a white to off-white crystalline powder with strict QC protocols including NMR, LC-MS, and elemental analysis. Store under inert conditions at 2-8??C to maintain stability. Ideal for cross-coupling reactions, amide formations, and heterocyclic scaffold modifications.

  • CAS No: 231291-22-8
  • Molecular Formula: C7H4F3NO2
  • Molecular Weight: 191.11
  • Exact Mass: 191.01941286
  • Monoisotopic Mass: 191.01941286
  • IUPAC Name: 6-(trifluoromethyl)pyridine-3-carboxylic acid
  • SMILES: C1=CC(=NC=C1C(=O)O)C(F)(F)F
  • Synonyms: 6-(Trifluoromethyl)nicotinic acid, 231291-22-8, 6-Trifluoromethylnicotinic acid, DTXSID20380558, DTXCID60331584

Application

6-(Trifluoromethyl)nicotinic acid serves as a key intermediate in the synthesis of trifluoromethyl-substituted pharmaceuticals, particularly kinase inhibitors and CNS-targeting agents. Its trifluoromethyl group improves lipophilicity and pharmacokinetic properties in drug discovery. The compound is also used in agrochemical research to develop herbicides and pesticides with enhanced environmental persistence. Researchers leverage its carboxylic acid moiety for peptide coupling or metal-catalyzed transformations.

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