Description

(6-Methoxypyridin-3-yl)boronic acid (CAS: 163105-89-3) is a high-purity boronic acid derivative widely used in pharmaceutical research, organic synthesis, and materials science. With the molecular formula C₆H₈BNO₃, this compound serves as a crucial intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds for drug discovery and advanced material development. Its methoxypyridine backbone enhances solubility and reactivity, making it ideal for synthesizing bioactive molecules, agrochemicals, and functionalized polymers. This product is rigorously tested to ensure ≥95% purity (HPLC/GC) and is supplied as a white to off-white crystalline powder, packaged under inert conditions to guarantee stability. Store in a cool, dry place away from moisture and light for optimal shelf life.

Properties

• CAS Number: 163105-89-3
• Complexity: 122
• IUPAC Name: (6-methoxy-3-pyridyl)boronic acid
• InChI: InChI=1S/C6H8BNO3/c1-11-6-3-2-5(4-8-6)7(9)10/h2-4,9-10H,1H3
• InChI Key: DHADXDMPEUWEAS-UHFFFAOYSA-N
• Exact Mass: 153.0597233
• Molecular Formula: C6H8BNO3
• Molecular Weight: 152.95
• SMILES: B(C1=CN=C(C=C1)OC)(O)O
• Topological: 62.6
• Monoisotopic Mass: 153.0597233
• Synonyms: (6-methoxypyridin-3-yl)boronic Acid, 672-299-1, 163105-89-3, 2-Methoxy-5-pyridineboronic acid, 2-Methoxypyridine-5-boronic acid, 6-methoxypyridin-3-ylboronic acid, 2-methoxy-5-pyridinylboronic acid, 6-methoxypyridine-3-boronic acid, 6-methoxy-pyridine-3-boronic acid, BORONIC ACID, B-(6-METHOXY-3-PYRIDINYL)-, 6-METHOXY-3-PYRIDINYLBORONIC ACID, MFCD02093044, 6-Methoxy-3-pyridylboronic Acid, 2-methoxy-5-pyridine boronic acid, 6-METHOXY-3-PYRIDINEBORONIC ACID, Boronic acid, (6-methoxy-3-pyridinyl)-, (6-methoxy-3-pyridyl)boronic acid, (6-methoxy-3-pyridinyl)boronic acid, 6-methoxypyridin-3-yl-3-boronic acid, SCHEMBL4942, YFU82Y97KF, 2-methoxy-5-pyridinboronic acid, CHEMBL3236876, 6-Methoxypyridin-3-boronic acid, DTXSID80370258, 2-methoxy-5-pyridin boronic acid, 2-methoxy-5-pyridyl-boronic acid, 2-methoxypyridin-5-ylboronic acid, 2-methoxy-5-pyridine-boronic acid, 2-methoxy-pyridine-5-boronic acid, 6-methoxy-3-pyridine boronic acid, (2-Methoxy-5-pyridyl)boronic acid, (6-methoxypyridin-3-yl)boronicAcid, 2-methoxypyridin-5-yl-boronic acid, 6-methoxy-3-pyridinyl-boronic acid, 6-methoxy-pyridin-3-ylboronic acid, 6-methoxypyridin-3-yl-boronic acid, BCP07170, 2-(methoxy)pyridine-5-boronic acid, (2-methoxy-5-pyridinyl)boronic acid, (2-methoxypyridin-5-yl)boronic acid, 6-methoxy-pyridin-3-yl boronic acid, 6-methoxy-pyridin-3-yl-boronic acid, BBL100442, SBB052568, STL554236, (6-methoxypyridin-3-yl) boronic acid, AKOS002670079, AB10717, AC-6982, CH-0005, CS-W019911, SB11188, (6-methoxy-pyridin-3-yl)-boronic acid, B-(6-Methoxy-3-pyridinyl)boronic acid, NCGC00663002-01, [6-(methyloxy)-3-pyridinyl]boronic acid, BP-10395, HY-32957, SY005271, DB-010465, DB-350605, M2029, EN300-56543, 6-Methoxy-3-pyridinylboronic acid, >=95.0%, A810445, Z858028390

(6-Methoxypyridin-3-yl)boronic acid is primarily employed in palladium-catalyzed cross-coupling reactions to construct biaryl scaffolds for drug candidates. It is also utilized in the synthesis of kinase inhibitors and other heterocyclic pharmacophores. Researchers value its compatibility with aqueous conditions and air-sensitive protocols. Suitable for high-throughput screening (HTS) and combinatorial chemistry applications.

Safety and Hazards

GHS Hazard Statements

• H302 (18.2%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (18.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (90.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (90.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (18.2%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (81.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (18.2%)
• Acute Tox. 4 (18.2%)
• Skin Irrit. 2 (90.9%)
• Eye Irrit. 2A (90.9%)
• Acute Tox. 4 (18.2%)
• STOT SE 3 (81.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.