Description
6-Methoxy-5-methylpyridin-3-amine (CAS No. 867012-70-2) is a high-purity heterocyclic organic compound with the molecular formula C7H10N2O. This specialized pyridine derivative features a methoxy group at the 6-position and a methyl group at the 5-position, making it a valuable intermediate for pharmaceutical research and fine chemical synthesis. With a molecular weight of 138.17 g/mol, it is supplied as a crystalline solid with ≥95% purity (HPLC). Ideal for medicinal chemistry applications, this compound is rigorously tested for consistency and stability, ensuring reliable performance in coupling reactions, heterocycle functionalization, and scaffold development. Available in research quantities (100mg to 10g) with optional custom packaging under inert atmosphere.
Properties
- CAS Number: 867012-70-2
- Complexity: 108
- IUPAC Name: 6-methoxy-5-methyl-pyridin-3-amine
- InChI: InChI=1S/C7H10N2O/c1-5-3-6(8)4-9-7(5)10-2/h3-4H,8H2,1-2H3
- InChI Key: RFEMLHVKBYMWAM-UHFFFAOYSA-N
- Exact Mass: 138.079312947
- Molecular Formula: C7H10N2O
- Molecular Weight: 138.17
- SMILES: CC1=CC(=CN=C1OC)N
- Topological: 48.1
- Monoisotopic Mass: 138.079312947
- Synonyms: 6-Methoxy-5-methylpyridin-3-amine, 867012-70-2, DTXSID10654558, DTXCID10605308, 804-608-4, 3-Amino-6-methoxy-5-methylpyridine, 5-AMINO-2-METHOXY-3-METHYLPYRIDINE, 3-Amino-6-methoxy-5-methyl-pyridine, 6-METHOXY-5-METHYL-PYRIDIN-3-YLAMINE, MFCD04972417, 3-Pyridinamine, 6-methoxy-5-methyl-, 6-METHOXY-5-METHYL-3-PYRIDINAMINE, SCHEMBL323074, RFEMLHVKBYMWAM-UHFFFAOYSA-N, 6-methoxy-5-methyl-3-pyridineamine, GEO-03674, AKOS011763952, AB20996, CS-W003211, AC-27508, AS-11469, SY022268, 5-Amino-2-methoxy-3-methylpyridine, 97%, EN300-197432
Application
6-Methoxy-5-methylpyridin-3-amine serves as a key building block in the synthesis of bioactive molecules, particularly in the development of kinase inhibitors and receptor modulators. Its electron-rich pyridine core facilitates palladium-catalyzed cross-coupling reactions for drug discovery pipelines. Researchers utilize this intermediate in the preparation of fused heterocycles for oncology and CNS-targeted therapeutics. The methoxy and methyl substituents enhance regioselectivity in nucleophilic aromatic substitution reactions.
Safety and Hazards
GHS Hazard Statements
- H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
- H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
- H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
- H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statements
- P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501
Hazard Classes and Categories
- Acute Tox. 4 (100%)
- Skin Irrit. 2 (100%)
- Eye Dam. 1 (100%)
- STOT SE 3 (100%)
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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.


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