Description

6-Methoxy-3-pyridinylamine (CAS No. 6628-77-9) is a high-purity organic compound with the molecular formula C₆H₈N₂O, widely used in pharmaceutical research, agrochemical development, and material science applications. This heterocyclic amine features a methoxy-substituted pyridine ring, offering unique reactivity for nucleophilic substitutions and coupling reactions. Our product is rigorously tested to ensure ≥95% purity (HPLC/GC), with strict quality control to minimize impurities such as residual solvents and heavy metals. Supplied as a crystalline solid with excellent shelf stability under recommended storage conditions (2-8°C in airtight containers), it is ideal for synthetic organic chemistry applications requiring precise building blocks. Available in research quantities (100mg to 10kg) with optional custom purity grades upon request.

Properties

• CAS Number: 6628-77-9
• Complexity: 87.1
• IUPAC Name: 6-methoxypyridin-3-amine
• InChI: InChI=1S/C6H8N2O/c1-9-6-3-2-5(7)4-8-6/h2-4H,7H2,1H3
• InChI Key: UUVDJIWRSIJEBS-UHFFFAOYSA-N
• Exact Mass: 124.063662883
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.14
• SMILES: COC1=NC=C(C=C1)N
• Topological: 48.1
• Monoisotopic Mass: 124.063662883
• Synonyms: 5-Amino-2-methoxypyridine, 6628-77-9, 2-Methoxy-5-aminopyridine, 3-Pyridinamine, 6-methoxy-, Pyridine, 5-amino-2-methoxy-, 6-Methoxy-3-pyridylamine, 6-methoxy-3-pyridinylamine, 6-methoxy-3-aminopyridine, EINECS 229-612-8, ATT39K5F0C, NSC 59708, BRN 0115155, 6-METHOXY-3-PYRIDINAMINE, 3-AMINO-6-METHOXYPYRIDINE, NSC-59708, DTXSID20216484, 5-22-11-00408 (Beilstein Handbook Reference), (2-METHOXYPYRIDIN-5-YL)AMINE, DTXCID20138975, 6-methoxypyridin-3-amine, MFCD00006264, 6-methoxy-pyridin-3-ylamine, 2-methoxy-5-amino pyridine, 5-amino-2-methoxy pyridine, NSC59708, Enamine_005501, 3-amino-6-methoxypyridin, 6-methoxypyridine-3-amine, UNII-ATT39K5F0C, 5-amino-2-methoxy pyridin, 6-methoxy-pyridin-3-amine, 6-methoxypyridin-3-ylamine, 2-methoxy-5-amino-pyridine, 3-amino-6-methoxy-pyridine, 5-amino-2-methoxy-pyridine, 5-Amino-2-methoxy pryidine, 2-methoxy-pyridin-5-ylamine, 6-(methoxy)-3-pyridinamine, SCHEMBL113293, SCHEMBL2642988, SCHEMBL8088294, CHEBI:194950, 5-Amino-2-methoxypyridine, 95%, HMS1409K01, ALBB-038584, BCP23177, STR03546, SBB016584, STK796795, AKOS000113302, AC-4382, CS-W001994, HY-W001994, PB27370, PS-5211, SY005187, DB-004398, DB-006941, A1956, NS00036006, ST45027819, EN300-17185, AO-080/40859930, Z56899049, F3284-8063

6-Methoxy-3-pyridinylamine serves as a key intermediate in the synthesis of bioactive molecules, particularly in developing kinase inhibitors and CNS-targeting pharmaceuticals. Its electron-rich pyridine core facilitates palladium-catalyzed cross-coupling reactions for constructing complex heterocycles. Researchers utilize this compound in medicinal chemistry for structure-activity relationship (SAR) studies due to its balanced lipophilicity and hydrogen bonding capacity. The methoxy group enhances metabolic stability in drug candidates while the amine functionality allows for versatile derivatization.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.