Description

6-(Fmoc-amino)-1-hexanol (CAS No. 127903-20-2) is a high-purity, synthetic organic compound with the molecular formula C₂₁H₂₅NO₃. This derivative features an Fmoc (9-fluorenylmethoxycarbonyl) protecting group, widely utilized in peptide synthesis for its orthogonal protection capabilities. The compound contains a hexanol backbone with a terminal hydroxyl group, making it a versatile linker or spacer molecule in solid-phase peptide synthesis (SPPS), bioconjugation, and material science applications. Its IUPAC name is 9H-fluoren-9-ylmethyl N-(6-hydroxyhexyl)carbamate, and it is characterized by excellent stability under basic conditions while being cleavable under mild acidic conditions. Ideal for researchers requiring precise control over amino group protection, this product is rigorously tested for purity (typically ≥95% by HPLC) and is supplied in a moisture-sensitive packaging to ensure long-term stability.

Properties

• CAS Number: 127903-20-2
• Complexity: 392
• IUPAC Name: 9H-fluoren-9-ylmethyl N-(6-hydroxyhexyl)carbamate
• InChI: InChI=1S/C21H25NO3/c23-14-8-2-1-7-13-22-21(24)25-15-20-18-11-5-3-9-16(18)17-10-4-6-12-19(17)20/h3-6,9-12,20,23H,1-2,7-8,13-15H2,(H,22,24)
• InChI Key: VGXOJZUTHIGHPT-UHFFFAOYSA-N
• Exact Mass: 339.18344366
• Molecular Formula: C21H25NO3
• Molecular Weight: 339.4
• SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCCCCCO
• Topological: 58.6
• Monoisotopic Mass: 339.18344366
• Synonyms: 6-(Fmoc-amino)-1-hexanol, 127903-20-2, (9H-Fluoren-9-yl)methyl (6-hydroxyhexyl)carbamate, 9H-fluoren-9-ylmethyl N-(6-hydroxyhexyl)carbamate, Carbamic acid, N-(6-hydroxyhexyl)-, 9H-fluoren-9-ylmethyl ester, (9H-FLUOREN-9-YL)METHYL N-(6-HYDROXYHEXYL)CARBAMATE, 6-Fmoc-Acp-ol, MFCD00380196, Fmoc-Acp(6)-ol, Maybridge1_008870, SCHEMBL887559, HMS566L04, DTXSID30371396, Carbamic acid, (6-hydroxyhexyl)-, 9H-fluoren-9-ylmethyl ester, AKOS015910691, AS-9476, CCG-255262, FF49780, 6-(Fmoc-amino)-1-hexanol, >=98.0%, CS-0149653, ST51037589, 9H-Fluoren-9-ylmethyl 6-hydroxyhexylcarbamate, W18763, EN300-5151267, (fluoren-9-ylmethoxy)-N-(6-hydroxyhexyl)carboxamide, N-(Fluoren-9-ylmethoxycarbonyl)-6-aminohexan-1-ol, 9-Fluorenylmethyl N-(6-hydroxyhexyl)carbamate;6-Fmoc-Acp-ol, Carbamic acid,N-(6-hydroxyhexyl)-,9H-fluoren-9-ylmethylester

Application

6-(Fmoc-amino)-1-hexanol is primarily used as a building block in peptide synthesis, where the Fmoc group protects the amine functionality during chain elongation. Its hydroxyl-terminated hexyl spacer enables conjugation to resins or other biomolecules, facilitating controlled immobilization in solid-phase assays. The compound is also employed in the development of drug-delivery systems and polymeric materials requiring cleavable linkers. Its compatibility with standard Fmoc deprotection conditions (e.g., piperidine) makes it a staple in automated peptide synthesizers.

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