Description

6-Fluoroquinolin-4-ol (CAS No. 391-78-6) is a high-purity fluorinated quinoline derivative with the molecular formula C₉H₆FNO. This heterocyclic compound, also known as 6-fluoro-1H-quinolin-4-one, is a valuable building block in pharmaceutical and agrochemical research due to its unique structural and electronic properties. The presence of both fluorine and hydroxyl groups on the quinoline scaffold enhances its reactivity and potential for derivatization. Our product is synthesized under strict quality control measures to ensure >98% purity (HPLC), with comprehensive analytical data including ¹H NMR, ¹³C NMR, and mass spectrometry available. Suitable for medicinal chemistry, material science, and as a precursor for fluorescent probes. Available in convenient packaging options from milligrams to kilogram quantities with custom synthesis available upon request.

Properties

• CAS Number: 391-78-6
• Complexity: 227
• IUPAC Name: 6-fluoro-1H-quinolin-4-one
• InChI: InChI=1S/C9H6FNO/c10-6-1-2-8-7(5-6)9(12)3-4-11-8/h1-5H,(H,11,12)
• InChI Key: BYZXOYSEYWCLOK-UHFFFAOYSA-N
• Exact Mass: 163.043341977
• Molecular Formula: C9H6FNO
• Molecular Weight: 163.15
• SMILES: C1=CC2=C(C=C1F)C(=O)C=CN2
• Topological: 29.1
• Monoisotopic Mass: 163.043341977
• Synonyms: 6-fluoroquinolin-4-ol, 670-764-3, 6-Fluoro-4-hydroxyquinoline, 391-78-6, 6-Fluoroquinolin-4(1H)-one, 21873-50-7, 6-fluoro-1H-quinolin-4-one, 4-Quinolinol, 6-fluoro-, 6-fluoro-4-quinolinol, MFCD00269610, F2156-0066, 4-hydroxy-6-fluoroquinoline, KUC100211, MFCD12190049, Oprea1_070300, SCHEMBL207627, SCHEMBL591523, SCHEMBL668615, SCHEMBL3465497, SCHEMBL19692752, SCHEMBL21052825, DTXSID40959907, KUC100211N, SMSSF-0533548, 6-Fluoroquinolin-4-ol, AldrichCPR, AAA39178, SBB018961, STK787842, 6-fluoro-4-oxo-1,4-dihydroquinoline, AKOS002336240, AKOS009158664, AB05527, AC-3046, FS-1084, SB68126, SY003657, DB-049385, ST4145793, CS-0044574, EN300-235812, Z431511916

Application

6-Fluoroquinolin-4-ol serves as a key intermediate in the synthesis of bioactive quinolone derivatives with potential antimicrobial and anticancer properties. The compound’s fluorinated quinoline core is particularly valuable in drug discovery for improving pharmacokinetic properties of lead compounds. Researchers utilize this building block to develop novel fluorescent markers for biological imaging applications. In material science, it finds use as a precursor for organic semiconductors and coordination complexes.

Safety and Hazards

GHS Hazard Statements

• H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (66.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (66.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (33.3%)
• Skin Irrit. 2 (66.7%)
• Eye Irrit. 2A (66.7%)
• STOT SE 3 (66.7%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.