Description

6-Fluoroquinazolin-4-amine (CAS No. 1190320-08-1) is a high-purity fluorinated quinazoline derivative with the molecular formula C₈H₆FN₃. This compound is a valuable building block in medicinal chemistry and pharmaceutical research, particularly in the development of kinase inhibitors and anticancer agents. Its unique structure, featuring a fluorine substituent at the 6-position and an amino group at the 4-position of the quinazoline core, enhances its reactivity and binding affinity in biological systems. Suitable for researchers and scientists, this product is rigorously tested for quality and consistency, ensuring reliable performance in synthetic applications. Available in various quantities to meet both small-scale and bulk research needs.

Properties

• CAS Number: 1190320-08-1
• Complexity: 164
• IUPAC Name: 6-fluoroquinazolin-4-amine
• InChI: InChI=1S/C8H6FN3/c9-5-1-2-7-6(3-5)8(10)12-4-11-7/h1-4H,(H2,10,11,12)
• InChI Key: ARIXAZJLBIBWSR-UHFFFAOYSA-N
• Exact Mass: 163.05457537
• Molecular Formula: C8H6FN3
• Molecular Weight: 163.15
• SMILES: C1=CC2=C(C=C1F)C(=NC=N2)N
• Topological: 51.8
• Monoisotopic Mass: 163.05457537
• Synonyms: 6-fluoroquinazolin-4-amine, 1190320-08-1, DTXSID20676529, DTXCID20627278, 959-539-3, 4-Amino-6-fluoroquinazoline, 4-QUINAZOLINAMINE, 6-FLUORO-, MFCD12024574, SCHEMBL18312194, ALBB-022291, AKOS006220922, FA43213, DS-15400, SY070633, DB-061502, CS-0084742, EN300-51564, C71622, Z727615778

Application

6-Fluoroquinazolin-4-amine is widely used as a key intermediate in the synthesis of biologically active compounds, particularly kinase inhibitors. Its fluorinated quinazoline scaffold is instrumental in the development of targeted anticancer therapies due to its ability to modulate enzyme activity. Researchers also utilize this compound in structure-activity relationship (SAR) studies to optimize drug candidates for improved efficacy and selectivity. Its applications extend to fluorescence labeling and other specialized chemical modifications in pharmaceutical R&D.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.