Description

6-Fluoropyridine-2-carboxylic acid (CAS: 402-69-7) is a high-purity fluorinated pyridine derivative with the molecular formula C₆H₄FNO₂. This compound is a versatile building block in pharmaceutical and agrochemical research, offering unique reactivity due to the fluorine substituent at the 6-position and the carboxylic acid functionality at the 2-position. It is supplied as a white to off-white crystalline powder with ≥97% purity (HPLC), ensuring optimal performance in synthetic applications. Ideal for coupling reactions, metal-catalyzed transformations, and heterocyclic synthesis, this reagent is rigorously tested for consistency and stability. Packaged under inert gas to prevent degradation, it is suitable for use in medicinal chemistry, material science, and as a ligand precursor.

Key Features:

• CAS: 402-69-7 | Molecular Weight: 141.10 g/mol
• High reactivity for nucleophilic substitution and cross-coupling
• Stored at 2-8°C to maintain integrity
• Available in 1g, 5g, 10g, and bulk quantities
• MSDS and analytical data (NMR, HPLC) provided

Properties

• CAS Number: 402-69-7
• Complexity: 140
• IUPAC Name: 6-fluoropyridine-2-carboxylic acid
• InChI: InChI=1S/C6H4FNO2/c7-5-3-1-2-4(8-5)6(9)10/h1-3H,(H,9,10)
• InChI Key: DIEMCUFYSOEIDU-UHFFFAOYSA-N
• Exact Mass: 141.02260653
• Molecular Formula: C6H4FNO2
• Molecular Weight: 141.10
• SMILES: C1=CC(=NC(=C1)F)C(=O)O
• Topological: 50.2
• Monoisotopic Mass: 141.02260653
• Synonyms: 6-Fluoropyridine-2-carboxylic acid, 637-034-6, 402-69-7, 6-Fluoropicolinic acid, 2-fluoropyridine-6-carboxylic acid, 6-Fluoro-2-pyridinecarboxylic acid, 2-Fluoro-6-pyridinecarboxylic acid, MFCD02181193, 6-Fluoro-pyridine-2-carboxylic acid, 2-Pyridinecarboxylic acid, 6-fluoro-, 2-fluoro-6-carboxypyridine, 6-Fluoropyridine-2-carboxylicacid, NSC16023, 6-fluoro picolinic acid, SCHEMBL107964, DTXSID00280229, DIEMCUFYSOEIDU-UHFFFAOYSA-N, BCP22178, 2-fluoro-6-pyridine carboxylic acid, 6-fluoro-2-pyridine carboxylic acid, BBL100489, NSC-16023, SBB028461, STL554283, AKOS002664370, AC-5947, CS-W019850, PS-9022, SY016861, 6-Fluoro-2-pyridinecarboxylic acid, 97%, F0837, ST50949592, EN300-96893, Z1203162000

6-Fluoropyridine-2-carboxylic acid is widely used as a key intermediate in the synthesis of bioactive molecules, including kinase inhibitors and antimicrobial agents. Its fluorine moiety enhances binding affinity in drug design, while the carboxylic acid group enables facile derivatization via amidation or esterification. Researchers employ it in Suzuki-Miyaura couplings to construct bipyridine scaffolds for catalytic systems. It also serves as a precursor for fluorinated liquid crystals and OLED materials due to its electron-withdrawing properties.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.