Description

6-Fluoropyridin-3-ol (CAS No. 55758-32-2) is a high-purity fluorinated pyridine derivative with the molecular formula C₅H₄FNO. This compound is a versatile heterocyclic building block widely used in pharmaceutical, agrochemical, and materials science research. Its IUPAC name, 6-fluoropyridin-3-ol, reflects its precise chemical structure featuring a fluorine substituent at the 6-position and a hydroxyl group at the 3-position of the pyridine ring.

Our product is synthesized under strict quality control to ensure exceptional purity (>98%) and consistency, making it ideal for demanding applications. It is supplied as a fine white to off-white crystalline powder with excellent solubility in common organic solvents such as DMSO, methanol, and acetonitrile. Proper storage under inert conditions at 2-8°C is recommended to maintain long-term stability.

Key applications include use as:

• Intermediate in drug discovery (particularly for kinase inhibitors and CNS-active compounds)
• Ligand precursor in catalysis
• Building block for fluorinated liquid crystals
• Agrochemical research

Safety data is provided in accordance with GHS standards. Please consult the SDS for proper handling procedures.

Properties

• CAS Number: 55758-32-2
• Complexity: 78.8
• IUPAC Name: 6-fluoropyridin-3-ol
• InChI: InChI=1S/C5H4FNO/c6-5-2-1-4(8)3-7-5/h1-3,8H
• InChI Key: HTRLNWYWOKWCLV-UHFFFAOYSA-N
• Exact Mass: 113.027691913
• Molecular Formula: C5H4FNO
• Molecular Weight: 113.09
• SMILES: C1=CC(=NC=C1O)F
• Topological: 33.1
• Monoisotopic Mass: 113.027691913
• Synonyms: 6-fluoropyridin-3-ol, 675-075-1, 2-Fluoro-5-hydroxypyridine, 55758-32-2, 6-Fluoro-3-pyridinol, 6-fluoro-3-hydroxypyridine, MFCD01075040, 3-PYRIDINOL, 6-FLUORO-, 6-fluoro-pyridin-3-ol, 3-hydroxy-6-fluoro-pyridine, SCHEMBL115215, SCHEMBL3096650, SCHEMBL29117161, DTXSID50376742, HTRLNWYWOKWCLV-UHFFFAOYSA-N, RB1138, AKOS005063779, AB08123, CS-W019887, PS-9244, AC-33391, SY022133, DB-024995, F0980, EN300-109417

Application

6-Fluoropyridin-3-ol serves as a key intermediate in medicinal chemistry, particularly in the synthesis of fluorinated drug candidates targeting various disease pathways. Its unique electronic properties make it valuable for developing kinase inhibitors and CNS-active pharmaceutical compounds. The compound also finds use in materials science as a precursor for fluorinated liquid crystals and specialty polymers. Researchers employ this building block to introduce both fluorine and hydroxyl functionalities in a single synthetic transformation.

Safety and Hazards

GHS Hazard Statements

• H302 (11.1%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (11.1%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (88.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (88.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (11.1%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (11.1%)
• Eye Irrit. 2A (88.9%)
• STOT SE 3 (88.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.